Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The protocol aims to investigate the effects of Chai hu administration on postmenopausal osteoporosis in ovariectomized (OVX) rats. Eight-week-old female Sprague-Dawley rats underwent bilateral ovariectomy using the dorsal approach to establish a postmenopausal osteoporosis model. Different doses of Chai hu oral liquid were administered by oral gavage for 12 consecutive weeks, followed by evaluations of bone microstructure and measurements of inflammatory cytokine levels. Medium- and high-dose Chai hu treatment partially inhibited bone loss, reduced pro-inflammatory cytokine expression, and upregulated anti-inflammatory cytokine levels in OVX rats. There was a significant reduction in the severity of bone destruction from low to high doses, and dose-related improvements in bone microstructural reconstruction were observed. Chai hu mitigated estrogen deficiency-induced bone loss and microstructural deterioration, thereby suppressing OP progression in this OVX model. This was likely to have resulted from the anti-inflammatory effects of the pathways involved.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3791/68675 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Estimated fracture risk in osteopenic patients with primary hyperparathyroidism.
Endocrine
September 2025
Otorhinolaryngology, Head and Neck Surgery, Candiolo Cancer Institute, FPO-IRCCS Turin, Turin, Italy.
Background: While osteoporosis in primary hyperparathyroidism (PHPT) is widely studied, PHPT patients with osteopenia remain less characterized. This study aimed to evaluate the prevalence, biochemical features, and estimated fracture risk of osteopenic PHPT patients in a real-life cohort.
Methods: We retrospectively analyzed a consecutive series of PHPT patients with available densitometric data at three sites.
The 2024 UK clinical guideline for the prevention and treatment of osteoporosis.
Arch Osteoporos
September 2025
School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Unlabelled: The National Osteoporosis Guideline Group (NOGG) has updated the revised UK guideline for the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women, and men age 50 years and older. This guideline is relevant for all healthcare professionals involved in osteoporosis management.
Introduction: The UK National Osteoporosis Guideline Group (NOGG) first produced a guideline on the prevention and treatment of osteoporosis in 2008, with updates in 2013, 2017 and 2021.
Multiple large language models versus clinical guidelines for postmenopausal osteoporosis: a comparative study of ChatGPT-3.5, ChatGPT-4.0, ChatGPT-4o, Google Gemini, Google Gemini Advanced, and Microsoft Copilot.
Arch Osteoporos
September 2025
Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan City, Taiwan.
Unlabelled: The study assesses the performance of AI models in evaluating postmenopausal osteoporosis. We found that ChatGPT-4o produced the most appropriate responses, highlighting the potential of AI to enhance clinical decision-making and improve patient care in osteoporosis management.
Purpose: The rise of artificial intelligence (AI) offers the potential for assisting clinical decisions.
The protocol aims to investigate the effects of Chai hu administration on postmenopausal osteoporosis in ovariectomized (OVX) rats. Eight-week-old female Sprague-Dawley rats underwent bilateral ovariectomy using the dorsal approach to establish a postmenopausal osteoporosis model. Different doses of Chai hu oral liquid were administered by oral gavage for 12 consecutive weeks, followed by evaluations of bone microstructure and measurements of inflammatory cytokine levels.
View Article and Find Full Text PDFImbalance of Bone Homeostasis Caused by Nrf2 Deficiency Leads to Bone Loss in OVX Rats.
Stem Cells Int
August 2025
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian, China.
Postmenopausal osteoporosis (PMOP) is a common bone metabolic disorder in middle-aged and elderly women, yet its pathogenesis remains unclear. This study investigates the effect of nuclear factor erythroid 2-related factor 2 (Nrf2) deficiency on bone homeostasis to provide insight into the mechanisms underlying PMOP. Sixteen female SD rats were randomly assigned to Sham and ovariectomized (OVX) groups.
View Article and Find Full Text PDF