More Than a Measure: Translating Frailty into Meaningful Care.

Clin J Am Soc Nephrol

Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.

Published: September 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.2215/CJN.0000000875DOI Listing

Publication Analysis

Top Keywords

measure translating
4
translating frailty
4
frailty meaningful
4
meaningful care
4
measure
1
frailty
1
meaningful
1
care
1

Similar Publications

Background: High % of low-voltage area (LVA), a surrogate of scar, is associated with atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). Noninvasive biomarkers of LVA are a medical need for PVI decision.

Objective: We aimed to identify the proteome profile of plasma extracellular vesicles (EVs) associated with high % LVA, their cellular origin, and their regulation by hyperglycemia.

View Article and Find Full Text PDF

Machine learning-based analysis of the impact of 5' untranslated region on protein expression.

Nucleic Acids Res

September 2025

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, No. 100 Waihuanxi Road, Guangzhou 510006, China.

The 5' untranslated region (5'UTR) plays a crucial regulatory role in messenger RNA (mRNA), with modified 5'UTRs extensively utilized in vaccine production, gene therapy, etc. Nevertheless, manually optimizing 5'UTRs may encounter difficulties in balancing the effects of various cis-elements. Consequently, multiple 5'UTR libraries have been created, and machine learning models have been employed to analyze and predict translation efficiency (TE) and protein expression, providing insights into critical regulatory features.

View Article and Find Full Text PDF

Purpose: To investigate the short-term impact of exposure to smoke from vegetation burns on ocular surface symptoms and signs.

Methods: Woody bushfuels were burnt in an enclosed room (Flammability Laboratory, University of Tasmania, Australia) to generate particulate matter and monitored in real time (Dust Trak II). Eighteen participants (aged 20-63 years, 8 males and 10 females) fitted with respirators were seated 1.

View Article and Find Full Text PDF

Background: Gastrointestinal bleeding (GiB) is associated with hypoperfusion, cytokine release, and alterations to the mucosal barrier frequently seen in the critical care population. Risk factors in the population at large have been well-studied, but few have specifically addressed the unique circumstances surrounding critically ill trauma patients. We aimed to evaluate the incidence and risk factors for GiB in the trauma critical care population.

View Article and Find Full Text PDF

Radiation therapy (RT) plays important roles in cancer treatment, and the efficacy of RT depends on the abscopal effect, which results in the regression of distant and untreated tumors through localized irradiation of a single tumor lesion. This effect is mediated by effector tumor antigen-specific T cells (ETASTs) activated by RT. Monitoring the radiation-induced changes in ETASTs can be used to predict the abscopal effect.

View Article and Find Full Text PDF