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Diabetes has become a major public health challenge due to its high prevalence and chronic nature, with many individuals managing the condition for decades. The vast heterogeneity in diabetes necessitates personalized approaches to its prevention, diagnosis, treatment, and prognosis. Recently, the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health convened experts from the fields of diabetes and AI to identify and discuss existing gaps, as well as potentially transformative opportunities and actionable items enabled by recent advancements in AI. One prominent theme that has emerged from this discussion was the considerable potential of AI in Diabetes Precision Health, a field that warrants greater attention. The purpose of this article is to describe the opportunities and challenges identified during the workshop and outline potential strategies recommended by workshop attendees to advance this promising field.
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http://dx.doi.org/10.1056/AIp2500475 | DOI Listing |
J Proteome Res
September 2025
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington 98195, United States.
Retinol binding protein 4 (RBP4), the circulating carrier of retinol, complexes with transthyretin (TTR) and is a potential biomarker of cardiometabolic disease. However, RBP4 quantitation relies on immunoassays and Western blots without retinol and TTR measurement. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous absolute quantitation of circulating RBP4 and TTR is critical to establishing their biomarker potential.
View Article and Find Full Text PDFJ Alzheimers Dis
September 2025
Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Università Campus Bio-Medico di Roma, Roma, Italy.
BackgroundAlzheimer's disease (AD) is the most common neurodegenerative disorder. While AD diagnosis traditionally relies on clinical criteria, recent trends favor a precise biological definition. Existing biomarkers efficiently detect AD pathology but inadequately reflect the extent of cognitive impairment or disease heterogeneity.
View Article and Find Full Text PDFDiabetologia
September 2025
Department of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
This review article, developed by the EASD Global Council, addresses the growing global challenges in diabetes research and care, highlighting the rising prevalence of diabetes, the increasing complexity of its management and the need for a coordinated international response. With regard to research, disparities in funding and infrastructure between high-income countries and low- and middle-income countries (LMICs) are discussed. The under-representation of LMIC populations in clinical trials, challenges in conducting large-scale research projects, and the ethical and legal complexities of artificial intelligence integration are also considered as specific issues.
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China.
Background: As a common postoperative neurological complication, postoperative delirium (POD) can lead to poor postoperative recovery in patients, prolonged hospitalization, and even increased mortality. However, POD's mechanism remains undefined and there are no reliable molecular markers of POD to date. The present work examined the associations of cerebrospinal fluid (CSF) sTREM2 with CSF POD biomarkers, and investigated whether the effects of CSF sTREM2 on POD were modulated by the core pathological indexes of POD (Aβ42, tau, and ptau).
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University.
Diabetic retinopathy (DR) remains a leading cause of preventable blindness worldwide, with the affected population projected to reach 270 million by 2045. Our study analyzed 2 434 interventional trials registered between 2007 and 2024 in the Informa Pharma Intelligence database and found that anti-VEGF agents dominate the therapeutic landscape-bevacizumab represents 24.0 % of studies, ranibizumab 15.
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