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Coronary artery bypass grafting (CABG) is a common surgical approach for advanced coronary artery disease unresponsive to conservative or percutaneous treatments. Despite its benefits in symptom relief and long-term outcomes, CABG is associated with notable postoperative respiratory complications. As such, respiratory physiotherapy plays a crucial role in recovery. The active cycle of breathing technique (ACBT) is a non-invasive, evidence-based method that promotes lung ventilation, secretion clearance, and respiratory function. This review aimed to describe the effectiveness of the ACBT in enhancing physiological and functional outcomes following CABG surgery. A review of PubMed and Google Scholar studies was conducted, with relevant articles analyzed for study design, patient profiles, intervention protocols, and clinical outcomes. Fifteen articles were included, encompassing studies on pulmonary complications following CABG, dosage and application of ACBT, its preventive role in postoperative pulmonary complications (PPCs), and its effects on respiratory and functional outcomes. The results of this review are expected to enhance clinicians' insight into selecting physical therapy to prevent PPCs. Pulmonary complications, including atelectasis and impaired gas exchange, are common after CABG and are primarily associated with anesthesia, surgical trauma, systemic inflammatory response, and impaired airway clearance. ACBT, consisting of breathing control, thoracic expansion, and forced expiration techniques, is a structured, non-invasive intervention designed to mobilize secretions and improve ventilation. It is typically applied 2-3 times per day over 2-5 days and often combined with incentive spirometry and conventional chest physiotherapy. The reviewed studies suggest that ACBT enhances oxygenation, improves lung volumes, and increases functional capacity. Additionally, ACBT helps reduce postoperative pain and dyspnea, contributing to overall recovery without reported adverse events. To conclude, ACBT is a safe, practical, and effective physiotherapeutic approach to support postoperative pulmonary recovery in CABG patients. Further well-designed trials are needed to validate and standardize its clinical use.
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http://dx.doi.org/10.2147/JMDH.S546054 | DOI Listing |
Clin J Am Soc Nephrol
September 2025
University College London Great Ormond Street Hospital for Children and Institute of Child Health, London, UK.
Background: Experience with icodextrin use in children on long-term peritoneal dialysis is limited. We describe international icodextrin prescription practices and their impact on clinical outcomes: ultrafiltration, blood pressure control, residual kidney function (RKF), technique and patient survival.
Methods: We included patients under 21 years enrolled in the International Pediatric Peritoneal Dialysis Network (IPPN) between 2007 and 2024, on automated PD with a daytime dwell.
Proc Natl Acad Sci U S A
September 2025
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
Agonist-induced interaction of G protein-coupled receptors (GPCRs) with β-arrestins (βarrs) is a critical mechanism that regulates the spatiotemporal pattern of receptor localization and signaling. While the underlying mechanism governing GPCR-βarr interaction is primarily conserved and involves receptor activation and phosphorylation, there are several examples of receptor-specific fine-tuning of βarr-mediated functional outcomes. Considering the key contribution of conformational plasticity of βarrs in driving receptor-specific functional responses, it is important to develop novel sensors capable of reporting distinct βarr conformations in cellular context.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Martin A. Fisher School of Physics, Brandeis University, Waltham, MA 02453.
Programmable self-assembly has recently enabled the creation of complex structures through precise control of the interparticle interactions and the particle geometries. Targeting ever more structurally complex, dynamic, and functional assemblies necessitates going beyond the design of the structure itself, to the measurement and control of the local flexibility of the intersubunit connections and its impact on the collective mechanics of the entire assembly. In this study, we demonstrate a method to infer the mechanical properties of multisubunit assemblies using cryogenic electron microscopy (cryo-EM) and RELION's multi-body refinement.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Lübeck, Lübeck, Germany.
Importance: Patients with inflammatory rheumatic diseases (IRDs) frequently experience psychological distress; however, access to psychological support remains limited.
Objective: To investigate the effectiveness of a digital psychological intervention for individuals with IRDs.
Design, Setting, And Participants: Participants aged 18 years or older were recruited across Germany between February 22 and June 4, 2024, if they had been diagnosed with rheumatoid arthritis, psoriatic arthritis, or systemic lupus erythematosus and reported psychological distress and reduced quality of life.
JAMA Netw Open
September 2025
School of Medicine and Public Health, University of Wisconsin-Madison, Madison.
Importance: It is unclear whether the duration of amyloid-β (Aβ) pathology is associated with neurodegeneration and whether this depends on the presence of tau.
Objective: To examine the association of longitudinal atrophy with Aβ positron emission tomography (PET)-positivity (Aβ+) and the estimated duration of Aβ+ (Aβ+ duration), controlling for tau-positivity.
Design, Setting, And Participants: Data for this longitudinal cohort study were drawn from the Wisconsin Registry for Alzheimer Prevention and the Wisconsin Alzheimer Disease Research Center Clinical Core Study.