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http://dx.doi.org/10.1016/j.oftale.2025.09.001 | DOI Listing |
PLoS Pathog
September 2025
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, California, United States of America.
The discovery of the endosymbiotic bacteria Wolbachia as an obligate symbiont of. filarial nematodes has led to antibiotic-based treatments for filarial diseases. While lab.
View Article and Find Full Text PDFAdv Physiol Educ
September 2025
Swansea University Medical School, Swansea University, Swansea, UK.
The chick embryo ventricular cardiomyocyte model provides students easy access to experiments involving fundamental features of cardiac cell physiology and pharmacology. Using standard physiology teaching laboratories and basic cell culture equipment, spontaneously beating colonies of electrically-connected cardiomyocytes can be obtained by the students themselves. Students learn, aseptic techniques and cell culture alongside experiments illustrating, at the simplest level of experimentation, how beating rate can be altered physiologically or pharmacologically.
View Article and Find Full Text PDFJ Phys Chem B
September 2025
School of Science, RMIT University, Melbourne 3000, Australia.
Pentameric ligand-gated ion channels control synaptic neurotransmission via an allosteric mechanism, whereby agonist binding induces global protein conformational changes that open an ion-conducting pore. For the proton-activated bacterial () ligand-gated ion channel (GLIC), high-resolution structures are available in multiple conformational states. We used a library of atomistic molecular dynamics (MD) simulations to study conformational changes and to perform dynamic network analysis to elucidate the communication pathways underlying the gating process.
View Article and Find Full Text PDFJ Chem Phys
September 2025
Department of Chemistry Education and Graduate Department of Chemical Materials, Pusan National University, Busan 46241, Republic of Korea.
Alkali salt-doped ionic liquids are emerging as promising electrolyte systems for energy applications, owing to their excellent interfacial stability. To address their limited ionic conductivity, various strategies have been proposed, including modifying the ion solvation environment and enhancing the transport of selected ions (e.g.
View Article and Find Full Text PDFJ Chem Phys
September 2025
Laboratoire de Chimie Théorique, Sorbonne Université and CNRS, F-75005 Paris, France.
We develop the theory justifying the application of the density-based basis-set correction (DBBSC) method to double-hybrid approximations in order to accelerate their basis convergence. We show that, for the one-parameter double hybrids based on the adiabatic connection, the exact dependence of the basis-set correction functional on the coupling-constant parameter λ involves a uniform coordinate scaling by a factor 1/λ of the density and of the basis functions. Neglecting this uniform coordinate scaling corresponds essentially to the recent work of Mester and Kállay, J.
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