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Functional neurological disorders are characterized by a variety of neurological symptoms that are not explained by an identifiable organic pathology. Despite their significant prevalence and major impact on quality of life, their recognition and management remain inadequate. Formerly known as hysteria, modern criteria (Diagnostic and Statistical Manual of Mental Disorders, 5th edition [DSM-5]) allow a positive diagnosis, distinct from malingering. These disorders often lead to long periods of misdiagnosis, high levels of care consumption and significant socio-economic repercussions, including frequent loss of employment. Improving the training of professionals, developing specific treatments, reducing stigmatization and providing support for patients are crucial to meeting this public health challenge.
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http://dx.doi.org/10.1016/j.revinf.2025.07.005 | DOI Listing |
Curr Opin Virol
September 2025
Infection Biology, Global Center for Pathogen and Human Health Research, Cleveland Clinic, Cleveland, OH 44195, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA. Electronic address:
Intracranial calcifications (ICCs) are a characteristic neuropathological feature of several congenital viral infections, including Zika virus (ZIKV), cytomegalovirus (CMV), and lymphocytic choriomeningitis virus (LCMV). These lesions are linked to severe neurodevelopmental outcomes, such as microcephaly, epilepsy, and cognitive deficits, yet the mechanisms underlying their formation and resolution remain unclear. ICCs are thought to arise from an imbalance in osteogenic and osteolytic signaling in the developing brain.
View Article and Find Full Text PDFCell Rep
September 2025
Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address:
Adenylosuccinate lyase deficiency (ADSLd) is a rare autosomal recessive purine metabolism disorder with several clinical manifestations. While toxic substrate accumulation is a known hallmark, no additional molecular mechanisms have been established. Here, we show that ADSLd is associated with mitochondrial dysfunction, including increased fragmentation, impaired respiration, and reduced ATP production.
View Article and Find Full Text PDFPituitary
September 2025
Facoltà Di Medicina E Chirurgia, Università Cattolica del Sacro Cuore, Rome, Italy.
Introduction: Pituitary adenomas (PAs) are generally benign neoplasms, though in rare cases may exhibit aggressive behavior. In 2024, the PANOMEN-3 workshop released a new clinical-pathological classification. The objective of this study was to examine the potential of the PANOMEN-3 classification to predict prognosis of PAs and guide treatment in our single center cohort of patients with PAs.
View Article and Find Full Text PDFOncogene
September 2025
Division of Neurosurgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
It has become evident from decades of clinical trials that multimodal therapeutic approaches with focus on cell intrinsic and microenvironmental cues are needed to improve understanding and treat the rare, inoperable, and ultimately fatal diffuse intrinsic pontine glioma (DIPG), now categorized as a diffuse midline glioma. In this study we report the development and characterization of an in vitro system utilizing 3D Tumor Tissue Analogs (TTA), designed to replicate the intricate DIPG microenvironment. The innate ability of fluorescently labeled human brain endothelial cells, microglia, and patient-derived DIPG cell lines to self-assemble has been exploited to generate multicellular 3D TTAs that mimic tissue-like microstructures, enabling an in- depth exploration of the spatio-temporal dynamics between neoplastic and stromal cells.
View Article and Find Full Text PDFClin Neurophysiol
September 2025
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Objective: To compare brain activity before voluntary movement and before the same movement when it was released from suppression. This study examined the Bereitschaftspotential (BP) and beta band event-related desynchronization (bERD) during active blink suppression, contrasting these with voluntary blinking, where these EEG correlates of motor preparation are well-established.
Methods: Fifteen healthy adults performed voluntary blink and blink suppression-release tasks with EEG recording.