Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: The purpose of this study was to evaluate whether the combination of cefazolin or a second-generation cephalosporin plus metronidazole is associated with a reduced risk of surgical site infection in women undergoing hysterectomy for gynecologic cancer compared to using cefazolin or a second-generation cephalosporin alone.
Methods: This was a retrospective cohort study of patients who underwent hysterectomy at a single institution between January 2020 and June 2022. The primary outcome was surgical site infection. All patients who underwent abdominal, robotic-assisted, or laparoscopic hysterectomy for presumed malignancy and received either a first- or second-generation cephalosporin with or without metronidazole, or gentamicin with clindamycin, were included in the analysis.
Results: A total of 1055 patients were identified who underwent hysterectomy for malignancy during the study period across 4 hospital sites within our system. The overall rate of any surgical site infection was 3.2% (N = 34). Surgical site infection was found to be independently associated with diabetes (p < .01), smoking (p < .01), and antibiotic regimen (p = .04). Surgical site infection rates were 4.3% among patients treated with standard-of-care antibiotics and 2.1% with the addition of metronidazole. However, after adjusting for covariates using a mixed-effects binary logistic regression, the addition of metronidazole to standard-of-care antibiotics was not statistically significantly associated with a reduced risk of surgical site infection (OR 0.5, 95% CI 0.3 to 1.1).
Conclusions: While there was evidence supporting an independent association between antibiotic regimen and surgical site infection rate, after adjusting for open incision, smoking status, and diabetes, there was no statistical difference in infection rates with the addition of metronidazole. Future studies with larger sample sizes are warranted to better elucidate these potentially important clinical effects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijgc.2025.102036 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Thromboembolic risks after knee arthroplasty in patients with severe obesity: A large-scale analysis using Japanese medical claims data.
J Orthop Sci
September 2025
Department of Health Administration and Policy, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi 980-8574, Japan. Electronic address:
Background: Obesity is associated with an increased risk of complications after total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA), particularly in Western populations. However, the effect of severe obesity (body mass index [BMI] ≥ 35 kg/m) on postoperative complications in Japanese patients remains unclear.
Methods: We conducted a retrospective cohort study using Japan's Diagnosis Procedure Combination (DPC) database, including patients who underwent TKA or UKA between April 2016 and March 2023.
Comparison of clinical features between patients with bone and soft tissue angiosarcomas.
J Orthop Sci
September 2025
Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido 060-8638, Japan. Electronic address:
Background: Angiosarcoma is a rare and aggressive malignancy arising from vascular endothelial cells, with distinct subtypes originating in bone (AS-B) and soft tissue (AS-ST). While these subtypes share pathological similarities, differences in clinical outcomes remain unclear due to limited data. This study aimed to compare the clinical features, treatment strategies, and survival outcomes between AS-B and AS-ST using the Surveillance, Epidemiology, and End Results (SEER) database.
View Article and Find Full Text PDFOptimal stimulation site and fiber tracts in subthalamic deep brain stimulation for Meige syndrome.
Brain Stimul
September 2025
Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, China; Department of Neurosurgery, Neuromedicine Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. Electronic address:
Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has emerged as an effective therapy for Meige syndrome (MS). However, the optimal stimulation site within STN and the most effective stimulation fiber tracts have not been investigated.
Methods: Based on the discovery cohort (n = 65), we first identified the optimal stimulation site within the STN using the sweet spot mapping method.
Addition of metronidazole to standard-of-care perioperative prophylaxis at the time of hysterectomy for gynecologic malignancies.
Int J Gynecol Cancer
August 2025
Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Long Island Jewish Medical Center, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, New Hyde Park, NY, USA; Northwell Health, Feinstein Institutes for Medical Research, Institute of Molecular Medicine, Manhas
Objective: The purpose of this study was to evaluate whether the combination of cefazolin or a second-generation cephalosporin plus metronidazole is associated with a reduced risk of surgical site infection in women undergoing hysterectomy for gynecologic cancer compared to using cefazolin or a second-generation cephalosporin alone.
Methods: This was a retrospective cohort study of patients who underwent hysterectomy at a single institution between January 2020 and June 2022. The primary outcome was surgical site infection.
Relationship of Adhesive Drapes on Groin Surgical Site Infection Prevention in Vascular Surgery.
J Surg Res
September 2025
Department of Vascular Surgery, Kettering Medical Center, Kettering, Ohio.
Introduction: Iodine impregnated adhesive drapes have been shown to reduce incidence of surgical site infection (SSI) in cardiothoracic surgery. A Cochrane review of its use in multiple specialties found significantly more SSIs in the adhesive group versus control. No studies have evaluated their use in vascular surgery and infrainguinal SSIs which this study sought to evaluate.
View Article and Find Full Text PDF