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Introduction: Emotion dysregulation is common in many different psychiatric disorders and it can be effectively treated with the well-established Dialectical Behavioral Therapy (DBT). Despite its clinical relevance and increasing scientific interest, emotional dysregulation (ED) is sometimes conflated with emotional lability (EL). However, these constructs differ: ED involves top-down neurobiological processes, while EL involves bottom-up processes. As psychotherapy essentially influences top-down processes compared to pharmacotherapy, this study aimed to investigate whether ED is more sensitive to DBT than EL.
Method: Our naturalistic study involved the 39 participants (sex ratio = 9 m/30w, mean age = 33.23) who completed questionnaires assessing ED (DERS-36) and EL (ALS-18) before then after transdiagnostic DBT skills training (DBT-ST). The diagnoses of participants included BPD (64 %), BD (23 %), ADHD (23 %), addiction (17 %) or eating disorder (17 %). DBT was performed in a transdiagnostic group over 4 months.
Result: After DBT-ST, ED improved significantly with a medium effect size (d = 0.73), while EL showed no significant change (d = 0.13). The percentages of improvement on DERS were significantly higher than on ALS (p < 0.002, d = 0.50). The correlation between these both measures decreased during therapy from r = 0.37 to r = 0.32.
Discussion: Our findings indicate that ED improved more than EL after DBT and that their correlation diminished during therapy. These results suggest that ED is a different process from EL and that ED is more sensitive to treatments like DBT Skills Training. To confirm these findings, further studies are needed ideally with larger sample size, long-term follow-up and a controlled design.
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http://dx.doi.org/10.1016/j.jad.2025.120199 | DOI Listing |
J Affect Disord
September 2025
SCP Psychiatry, 1170 Pontiac Avenue, Cranston, RI, 02920, United States.
Background: Emotion dysregulation and social functioning are important predictors of depression severity. It remains unclear whether these factors independently or interactively contribute to depression severity amongst psychiatric patients with depressive disorders.
Method: 340 psychiatric outpatients with a principal depressive disorder were interviewed using the Structured Clinical Interview for DSM-IV (SCID).
J Affect Disord
September 2025
Department of Psychiatry, Strasbourg University Hospitals, France; Faculty of Medicine, Maieutic and Health Sciences, University of Strasbourg, France; INSERM UMR_S 1329, Team Psychiatry, Department of Psychiatry, Strasbourg, France. Electronic address:
Introduction: Emotion dysregulation is common in many different psychiatric disorders and it can be effectively treated with the well-established Dialectical Behavioral Therapy (DBT). Despite its clinical relevance and increasing scientific interest, emotional dysregulation (ED) is sometimes conflated with emotional lability (EL). However, these constructs differ: ED involves top-down neurobiological processes, while EL involves bottom-up processes.
View Article and Find Full Text PDFJ Affect Disord
September 2025
Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy; Department of Neuroscience, University of Pisa Hospital, Pisa, Italy.
Emotion dysregulation (ED), a core feature of Bipolar Disorder (BD), contributes to symptom severity, mood instability, and reduced quality of life. Emerging evidence suggests that interoception-the ability to perceive and integrate internal bodily signals-may play a pivotal role in shaping emotional experience. However, the relationship between interoceptive sensibility and ED in BD remains poorly understood.
View Article and Find Full Text PDFStress-related conditions disrupt cognition and emotion regulation and can result in psychiatric illness, but the neural circuit-level changes that can explain these broad effects remain unclear. To address this issue, we paired population-grounded discovery with out-of-sample testing. Using resting-state fMRI from > 14,000 healthy adults in the UK Biobank, we derived connectivity profiles tied to cognition (reaction time, numeric memory), and proxies of emotion dysregulation (neuroticism, anhedonia).
View Article and Find Full Text PDFFront Aging Neurosci
August 2025
Laboratory of Sensory Neurobiology, School of Basic Medical Sciences, Hebei University, Baoding, China.
Age-related hearing loss (ARHL), or presbycusis, is characterized by a progressive decline in binaural auditory sensitivity, particularly affecting high-frequency hearing and sound localization. The pathogenesis of ARHL is still unclear, correspondingly reflected in a lack of clinically effective intervention strategies. Recent advancements in audiology and neurobiology have illuminated the black box of the pathogenesis of ARHL.
View Article and Find Full Text PDF