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Multivariate time series anomaly detection has shown potential in various fields, such as finance, aerospace, and security. The fuzzy definition of data anomalies, the complexity of data patterns, and the scarcity of abnormal data samples pose significant challenges to anomaly detection. Researchers have extensively employed autoencoders (AEs) and generative adversarial networks (GANs) in studying time series anomaly detection methods. However, relying on reconstruction error, the AE-based anomaly detection algorithm needs more effective regularization methods, rendering it susceptible to the problem of overfitting. Meanwhile, GAN-based anomaly detection algorithms require high-quality training data, significantly impacting their practical deployment. We propose a novel GAN based on a dual-discriminator structure to address these issues. The model first processes the data with the generator to obtain the reconstruction error and then calculates pseudo-labels to divide the data into two categories. One data category is input into the first discriminator, where a minor loss between the data and its reconstructed counterpart is better. The other data category is input into the second discriminator, where a larger loss between the data and its reconstructed counterpart is better. Through this process, the model can effectively constrain the generator, retaining information on normal data during data reconstruction while discarding information on abnormal data. After conducting experiments on multiple benchmark datasets, the proposed GAN based on a dual-discriminator structure achieved good results in anomaly detection, outperforming several advanced methods. Additionally, the model also performed well in practical transformer data.
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http://dx.doi.org/10.1109/TNNLS.2025.3585978 | DOI Listing |
BMC Neurol
September 2025
Department of Neurology, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, Aachen, North Rhine-Westphalia, Germany.
Background: Cerebellar pathologies in adults can have a wide range of hereditary, acquired and sporadic-degenerative causes. Due to the frequency in daily hospital, especially intensive care, settings, electrolyte imbalances are an important, yet rare differential diagnosis. The hypomagnesemia-induced cerebellar syndrome (HiCS) constitutes a relevant disease entity with clinical and morphological variability due to a potential progression of symptoms and a promising causal treatment.
View Article and Find Full Text PDFAJNR Am J Neuroradiol
September 2025
From the Department of Otorhinolaryngology Head and Neck Surgery (J.G., Y.L., S.G.) and Department of Radiology (N.X., R.T., H.D.,Z.Y., Z.W., P.Z.), Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Background And Purpose: Isolated congenital middle ear malformation contributes significantly to congenital hearing loss and growth problems. This study aims to compare 0.1 mm isotropic ultra-high-resolution computed tomography and conventional high-resolution computed tomography for assessing isolated congenital middle ear malformation, using surgical exploration as the gold standard.
View Article and Find Full Text PDFCell Rep Med
August 2025
Center for Biomedical-photonics and Molecular Imaging, Advanced Diagnostic-Therapy Technology and Equipment Key Laboratory of Higher Education Institutions in Shaanxi Province, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China; Engineering Research Center of Mole
Rapid identification and accurate diagnosis are critical for individuals with acute leukemia (AL). Here, we propose a combined deep learning and surface-enhanced Raman scattering (DL-SERS) classification strategy to achieve rapid and sensitive identification of AL with various subtypes and genetic abnormalities. More than 390 of cerebrospinal fluid (CSF) samples are collected as targets, encompassing healthy control, AL patients, and individuals with other diseases.
View Article and Find Full Text PDFJ Am Soc Nephrol
September 2025
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Background: Genetic modifiers are believed to play an important role in the onset and severity of polycystic kidney disease (PKD), but identifying these modifiers has been challenging due to the lack of effective methodologies.
Methods: We generated zebrafish mutants of IFT140, a skeletal ciliopathy gene and newly identified autosomal dominant PKD (ADPKD) gene, to examine skeletal development and kidney cyst formation in larval and juvenile mutants. Additionally, we utilized ift140 crispants, generated through efficient microhomology-mediated end joining (MMEJ)-based genome editing, to compare phenotypes with mutants and conduct a pilot genetic modifier screen.
Mol Pharm
September 2025
Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
Myocardial fibrosis, a key pathological feature of hypertensive heart disease (HHD), remains diagnostically challenging due to limited clinical tools. In this study, a FAPI-targeted uptake mechanism previously reported by our group, originally developed for tumor imaging, is extended to the detection of myocardial fibrosis in HHD using [F]F-NOTA-FAPI-MB. The diagnostic performance of this tracer is compared with those of [F]F-FDG, [F]F-FAPI-42, and [F]F-NOTA-FAP2286, and its potential for fluorescence imaging is also evaluated.
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