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http://dx.doi.org/10.1002/ppul.71276 | DOI Listing |
Int J Radiat Oncol Biol Phys
September 2025
Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Electronic address:
Purpose / Introduction: The BLINDED FOR REVIEW trial investigated the maximum tolerated dose for ultracentral lung tumors treated with stereotactic body radiotherapy (SBRT). Here we report a spatial and dosimetric secondary analysis of the treatment plans and assess relationships between doses to targets, organs-at-risk (OARs) and clinical outcomes.
Material And Methods: Five institutions enrolled patients with ultracentral lung cancer, cT1-3N0M0, and all received 60 Gy in 8 fractions.
Pediatr Pulmonol
September 2025
University of Iowa Health Care, Iowa City.
Drugs Aging
September 2025
Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY, USA.
Cardiovascular disease remains the leading cause of morbidity and mortality among older adults, who often face unique challenges in preventive care due to multimorbidity, frailty, and polypharmacy. The polypill, a fixed-dose combination of multiple cardiovascular medications, has emerged as a promising strategy to improve adherence, simplify treatment, and reduce the burden of major cardiovascular events. This review aims to synthesize current evidence supporting polypill use in both primary and secondary prevention, with a particular focus on older populations.
View Article and Find Full Text PDFMed Phys
August 2025
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Background: Low-field MRI provides superior soft-tissue contrast compared to CT while costing significantly less than high-field MRI, which makes it a more accessible option for MRI-guided radiation therapy planning. Four-dimensional MRI (4D-MRI) is a technique that has been increasingly adopted clinically for internal target volume (ITV) delineation in free-breathing liver radiotherapy planning, and it requires high spatial resolution and accurate respiratory phase differentiation to enable precise dose planning. The feasibility of 4D-MRI at low-field strength, specifically at 0.
View Article and Find Full Text PDFSci Transl Med
September 2025
Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
The rapid emergence of divergent SARS-CoV-2 variants led to a 2023-2024 update of the COVID-19 mRNA vaccine to a monovalent version containing the XBB.1.5 SARS-CoV-2 spike antigen.
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