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Autonomous systems operating in high-dimensional environments increasingly rely on prioritization heuristics to allocate attention and assess risk, yet these mechanisms can introduce cognitive biases such as salience, spatial framing, and temporal familiarity that influence decision-making without altering the input or accessing internal states. This study presents Priority Inversion via Operational Reasoning (PRIOR), a black-box, non-perturbative diagnostic framework that employs structurally biased but semantically neutral scenario cues to probe inference-level vulnerabilities without modifying pixel-level, statistical, or surface semantic properties. Given the limited accessibility of embodied vision-based systems, we evaluate PRIOR using large language models (LLMs) as abstract reasoning proxies to simulate cognitive prioritization in constrained textual surveillance scenarios inspired by Unmanned Aerial Vehicle (UAV) operations. Controlled experiments demonstrate that minimal structural cues can consistently induce priority inversions across multiple models, and joint analysis of model justifications and confidence estimates reveals systematic distortions in inferred threat relevance even when inputs are symmetrical. These findings expose the fragility of inference-level reasoning in black-box systems and motivate the development of evaluation strategies that extend beyond output correctness to interrogate internal prioritization logic, with implications for dynamic, embodied, and visually grounded agents in real-world deployments.
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http://dx.doi.org/10.3389/frai.2025.1623573 | DOI Listing |
Front Pediatr
August 2025
Pediatrics Department, Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan, Russia.
Background: Acid sphingomyelinase deficiency (ASMD) type A/B, a rare lysosomal storage disorder caused by biallelic mutations in the SMPD1 gene, presents with variable visceral and neurological manifestations. Arnold-Chiari malformation is a structural defect of the cerebellum and brainstem with distinct pathogenesis and clinical course. To our knowledge, the coexistence of these two conditions has not been previously reported.
View Article and Find Full Text PDFAlpha Psychiatry
August 2025
Information Sciences and Technology, George Mason University, Fairfax, VA 22030, USA.
Background: Herein, we report on the initial development, progress, and future plans for an autonomous artificial intelligence (AI) system designed to manage major depressive disorder (MDD). The system is a web-based, patient-facing conversational AI that collects medical history, provides presumed diagnosis, recommends treatment, and coordinates care for patients with MDD.
Methods: The system includes seven components, five of which are complete and two are in development.
Front Neural Circuits
September 2025
Faculty of Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan.
Neuronal networks in animal brains are considered to realize specific filter functions through the precise configuration of synaptic weights, which are autonomously regulated without external supervision. In this study, we employ a single Hodgkin-Huxley-type neuron with autapses as a minimum model to computationally investigate how spike-timing-dependent plasticity (STDP) adjusts synaptic weights through recurrent feedback. The results show that the weights undergo oscillatory potentiation or depression with respect to autaptic delay and high-frequency stimulation.
View Article and Find Full Text PDFJ Appl Toxicol
September 2025
School of Public Health, Key Laboratory of Special Environmental and Health Research, Xinjiang Medical University, Urumqi, China.
Humans' exposure to arsenic (As) has been associated with the development of various diseases. Some health effects may be mediated by arsenic-induced toxicity to the thyroid and endocrine systems, but its underlying mechanisms remain unclear. The overall aim of our study was focused on using sodium arsenite (NaAsO)-exposed rats to investigate the involvement of the phosphatidylinositol 3-kinase (PI3K) and transcription factor NF-E2-related factor 2 (Nrf2) pathways in toxicity to the thyroid and endocrine systems.
View Article and Find Full Text PDFNat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
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