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Article Abstract
Significance: Broadband near-infrared spectroscopy (bNIRS) can simultaneously monitor several chromophores, including the oxidative state of cytochrome c-oxidase (oxCCO), an oxygen metabolism biomarker, the activity of which is altered in Alzheimer's disease. Being a portable and noninvasive neuromonitoring technique, bNIRS could provide accessibility to brain-specific biomarkers and aid in the dementia diagnostic pathway.
Aim: We use bNIRS-recorded functional hemodynamic and oxCCO changes to assess their relevance in Alzheimer's disease diagnosis.
Approach: Using a visual stimulus paradigm, we recorded functional changes in oxy-, deoxy-hemoglobin and oxCCO in three similarly aged cohorts: healthy controls ( ), individuals with mild cognitive impairment ( ), and individuals with early Alzheimer's dementia ( ). We then selected features from these functional responses to find the best correlation with clinical cognitive markers (cognitive and behavioral test scores and clinical diagnoses) using canonical correlation analysis (CCA).
Results: We found individual variations in peak amplitude and time-to-peak for all the stimulus-evoked bNIRS signals across the three cohorts. CCA showed a strong correlation between bNIRS features and the clinical cognitive markers ( ). However, repeating the same analysis by excluding the bNIRS oxCCO features leads to a significantly lower correlation ( ) with the clinical markers.
Conclusions: oxCCO could be a crucial biomarker, partly explaining cognitive differences with dementia. bNIRS uniquely provides a portable and noninvasive technique to monitor several chromophores simultaneously, including oxCCO, with potential future applications in diagnosing and tracking dementia progression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407020 | PMC |
| http://dx.doi.org/10.1117/1.JBO.30.S2.S23910 | DOI Listing |
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