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The rapidly growing computational demands of artificial intelligence (AI) and complex optimization tasks are increasingly straining conventional electronic architectures, driving the search for novel, energy-efficient processing paradigms. Photonic computing, which harnesses the unique properties of light to perform computation, has emerged as a compelling alternative. This perspective highlights a key advancement: a versatile nonlinear optoelectronic engine based on integrated photodetectors and micro-ring modulators (PD + MRM). This engine enables crucial functionalities like nonlinear activation and signal relay, forming a core building block for monolithic photonic processors. Its application in integrating optical Ising machines for optimization and optical recurrent neural networks (RNNs) for AI has been examined recently. The PD + MRM unit's inherent compactness, efficiency, and on-chip reconfigurable nonlinearity address historical photonic computing challenges, signaling a shift towards more versatile and scalable monolithic photonic processors.
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http://dx.doi.org/10.1038/s41377-025-01970-3 | DOI Listing |
Indian J Nucl Med
August 2025
Department of Nuclear Medicine, Jawaharlal Institute of Post-Graduate Medical Education and Research, Puducherry, India.
Objectives: Bone scintigraphy is a sensitive imaging method to evaluate patients with suspected osteonecrosis. We assessed the diagnostic performance of combined bone single-photon emission computed tomography/computed tomography (SPECT/CT) (CBS) in patients with known rheumatic disease or other connective tissue disorders and clinical suspicion of osteonecrosis compared to magnetic resonance imaging (MRI).
Methods: This prospective diagnostic accuracy study included 70 patients with clinical suspicion of osteonecrosis in any bone who underwent a planar triple-phase bone scan along with a regional SPECT/CT (CBS) and regional MRI.
Indian J Nucl Med
August 2025
Department of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
The patient, a 37-year-old male, initially presented with per rectal bleed. Colonoscopy revealed a circumferential lesion within the lower rectum, along with a few satellite lesions. At that time, we performed a biopsy, but the histopathological examination revealed consistent solitary rectal ulcer syndrome.
View Article and Find Full Text PDFMed Phys
September 2025
Medical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Background: Se ( 120 days, 215 keV) offers advantages over Ir ( 74 days, 360 keV) as a high dose rate brachytherapy source due to its lower gamma energy and longer half-life. Despite its widespread use in industrial gamma radiography, a Se brachytherapy source has yet to be manufactured.
Purpose: A novel Se-based source design with a vanadium diselenide core, titled the SeCure source, was proposed.
Parkinsonism Relat Disord
September 2025
Clinical Neurosciences, University of Turku, Turku, Finland; Neurocenter, Turku University Hospital, Turku, Finland. Electronic address:
Introduction: Sarcopenia, the age-related loss of muscle mass and function, has been reported in Parkinson's disease (PD). While grip strength is a key marker of sarcopenia and has been linked to PD risk and progression, its relationship with underlying neurodegenerative processes remains unclear. This study examines whether grip strength is impaired in PD and reflects disease severity or dopaminergic function.
View Article and Find Full Text PDFJ Appl Clin Med Phys
September 2025
Department of Radiation Oncology, University of Utah, Salt Lake City, Utah, USA.
Purpose: The development of on-board cone-beam computed tomography (CBCT) has led to improved target localization and evaluation of patient anatomical change throughout the course of radiation therapy. HyperSight, a newly developed on-board CBCT platform by Varian, has been shown to improve image quality and HU fidelity relative to conventional CBCT. The purpose of this study is to benchmark the dose calculation accuracy of Varian's HyperSight cone-beam computed tomography (CBCT) on the Halcyon platform relative to fan-beam CT-based dose calculations and to perform end-to-end testing of HyperSight CBCT-only based treatment planning.
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