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Article Abstract
Introduction: This study aimed to investigate the influence of benznidazole (BZN) origin on its in vitro potency against various Trypanosoma cruzi strains.
Methods: Pure BZN, purified BZN, and the pharmaceutical formulation Abarax were evaluated for their activity against several parasite strains.
Results: Results demonstrated significant variability in BZN's effectiveness, contingent upon both its specific form and the T. cruzi strain under investigation. Half-maximal inhibitory concentrations (IC values) exhibited a wide range, indicating that the potency of BZN is not uniform across all its forms or against all parasite strains.
Conclusion: In conclusion, this study elucidates the complex interaction between BZN and T. cruzi. The parasite's response to BZN can vary even within a single strain, influenced by the drug's specific presentation. These findings underscore the critical importance of considering both parasite diversity and drug formulation when assessing the efficacy of treatments in laboratory assays.
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