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Background: Sub-Saharan Africa accounts for the majority of child pneumonia mortality and morbidity. The pooled recovery rate of children from pneumonia and its predictors is not well known in Ethiopia.
Aim: The aim of this systematic review and meta-analysis is to determine the pooled recovery rate of children from pneumonia and its predictors in Ethiopia.
Methods: The major databases used to search articles were Web of Science, Science Direct, PubMed, Google Scholar, and African journals online. The data were extracted independently from eligible primary studies using a standardized spreadsheet. The quality of the included studies was assessed using the Newcastle-Ottawa scale critical appraisal checklist for the cohort study. The pooled effect size with a 95% CI was estimated by the random-effects model of meta-analysis. The amount of heterogeneity across the studies was assessed by . A sensitivity analysis was conducted.
Results: In this systematic review and meta-analysis, 6173 children with pneumonia were included; out of these, 4871 had recovered. The pooled recovery rate of children from pneumonia was 17.7 (95% CI: 14.61-20.79) per 100 children per day. Children who lived in rural areas (AHR = 0.81, 95% CI: 0.74-0.88), stunted children (AHR = 0.77, 95% CI: 0.56-0.99), children with dangerous signs (AHR = 0.78, 95% CI: 0.66-0.9), not fully vaccinated children (AHR = 0.55, 95% CI: 0.11-0.99), comorbid children (AHR = 0.57, 95% CI: 0.48-0.65), and children with a history of respiratory infection (AHR = 0.86, 95% CI: 0.76-0.96) had a lower recovery rate from pneumonia.
Conclusion: In the current study, the recovery rate of children from pneumonia was 17.7 per 100 child-days. Children living in rural areas recovered more slowly. Healthcare providers should give special attention at admission for screening of children with stunted, danger signs, not fully vaccinated, comorbid, and histories of respiratory tract infection.
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http://dx.doi.org/10.1002/hsr2.71127 | DOI Listing |
Bull Math Biol
September 2025
Department of Mathematics, Siena University, 515 Loudon Road, Loudonville, NY, 12211, USA.
Autonomous differential equation compartmental models hold broad utility in epidemiology and public health. However, these models typically cannot account explicitly for myriad factors that affect the trajectory of infectious diseases, with seasonal variations in host behavior and environmental conditions as noteworthy examples. Fortunately, using non-autonomous differential equation compartmental models can mitigate some of these deficiencies, as the inclusion of time-varying parameters can account for temporally varying factors.
View Article and Find Full Text PDFBull Math Biol
September 2025
Department of Mathematics and Faculty of Medicine, The University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Host defense and pathogen virulence interact and mutually shape each other's evolution. Host-pathogen co-evolutionary outcomes have potentially significant impacts on population dynamics and vice versa. To investigate host-pathogen interactions and explore the impact of micro-level co-evolutionary outcomes on macro-level epidemics, we develop a co-evolutionary model with a combined host-defense strategy.
View Article and Find Full Text PDFEur Heart J
September 2025
Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
Background And Aims: Fulminant myocarditis (FM) is a complex clinical syndrome characterized by acute myocardial inflammation and cardiogenic shock. Evidence on long-term outcomes, mortality risk factors, and targeted treatment options remains limited.
Methods: This retrospective analysis included consecutive adult patients admitted for FM between January 2012 and November 2022 at 26 European tertiary centres.
Microbiol Spectr
September 2025
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA.
Unlabelled: (SA) colonizes most mammals but also represents a danger in clinical settings because it evolves resistance against antibiotics, and SA infections represent a leading cause of death worldwide. SA nasal carriage provides the bacterial reservoir for opportunistic infection because clinical strains often match the patient's own nasally carried strain. The global SA carriage rate is typically reported as 25%-30% after sampling subjects once or twice and defining carrier status using culture-based methods.
View Article and Find Full Text PDFMult Scler
September 2025
Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, VA Medical Center, TN Valley Healthcare System, Nashville, TN, USA.
Background: There is limited knowledge on the post-glymphatic structures such as the parasagittal dural (PSD) space and the arachnoid granulations (AGs) in multiple sclerosis (MS).
Objectives: To evaluate differences in volume and macromolecular content of PSD and AG between people with newly diagnosed MS (pwMS), clinically isolated syndrome (pwCIS), or radiologically isolated syndrome (pwRIS) and healthy controls (HCs) and their associations with clinical and radiological disease measures.
Methods: A total of 69 pwMS, pwCIS, pwRIS, and HCs underwent a 3.