98%
921
2 minutes
20
Background: The high prevalence of functional neurological disorders (FND) in specialized neurological services such as epilepsy centers or dizziness clinics is well established. Few studies exist that investigate the frequency of FND among neurology in-patients.
Methods: In-hospital patients with functional neurological symptoms as part of the presenting complaint were identified by combining prospective and retrospective case ascertainment over a period of 2 years. Demographic and clinical features as well as reimbursements were analyzed.
Results: Across a total of 4648 in-hospital patients, 267 (5.7%) had functional neurological symptoms as a presenting complaint, and 217 (4.7%) were given a standalone FND diagnosis. All age groups and subtypes of FND were represented. FND comprised 2.4% of all cases admitted to the stroke unit for suspected stroke; 11.8% of all cases undergoing specialized epileptological workup; and 7.6% of cases admitted through the emergency department with a seizure disorder. Diagnostic coding of FND was inconsistent and associated with significantly lower per-day revenue when performed accurately.
Conclusions: FND is the third most common diagnosis among in-hospital neurological patients, which stands in stark contrast to its underrepresentation in clinical training, service provision, and research funding. Stroke-like presentations and seizures are common forms of FND among emergency admissions. Reimbursement mechanisms of the diagnosis-related groups system might disincentivize accurate diagnostic coding and contribute to a cycle of neglect within health care.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406976 | PMC |
http://dx.doi.org/10.1111/ene.70338 | DOI Listing |
Cereb Cortex
August 2025
Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Marseille 13005, France.
Over three decades, statistical parametric mapping has transformed neuroimaging from descriptive mapping to causal inference, placing generative models at the core of causal explanations for brain function. It inspired to a large degree The Virtual Brain, which builds subject-specific digital twins from multimodal data, enabling brain simulations and exploration. Both frameworks converge at parameter estimation, where model and data meet, providing the mathematical manifestation of cause-effect in pathophysiology.
View Article and Find Full Text PDFCereb Cortex
August 2025
The Clinical Hospital of Chengdu Brain Sciences Institute, University of Electronic Sciences and Technology of China (UESTC), 2006 Xiyuan Avenue, West Hi Tech Zone, 611731, Chengdu, China.
This commentary reflects three decades of interaction between the Cuban neuroinformatics tradition and the statistical parametric mapping (SPM) framework. From the early development of neurometrics in Cuba to global initiatives like the Global Brain Consortium, our trajectory has paralleled and intersected with that of SPM. We highlight shared commitments to generative modeling, Bayesian inference, and population-level brain mapping, as shaped through collaborations, workshops, and joint theoretical work with Karl Friston and his group.
View Article and Find Full Text PDFCereb Cortex
August 2025
Department of Psychology, University of Milano-Bicocca, Milan, Italy.
Semantic composition allows us to construct complex meanings (e.g., "dog house", "house dog") from simpler constituents ("dog", "house").
View Article and Find Full Text PDFProbiotics Antimicrob Proteins
September 2025
Operational Research Centre in Healthcare, Near East University, Nicosia, Cyprus.
Probiotics are live beneficial microorganisms that confer health benefits to the host when administered in adequate amounts, have gained considerable scientific and commercial interest for their ability to support gut health, strengthen immunity, and reduce disease risk. This review traces the genesis of probiotic science from its origins in traditional fermented foods to contemporary clinical applications, offering a conceptual understanding of its evolution. A clear distinction is drawn between endogenous probiotics, naturally resident in the human microbiome, and exogenous probiotics, introduced via dietary supplements and functional foods.
View Article and Find Full Text PDFMar Biotechnol (NY)
September 2025
Yazhou Bay Innovation Institute, Hainan Tropical Ocean University, Sanya, China.
Epinephelus tukula is an economically important aquaculture animal, and a major parent in grouper crossbreeding. To better preserve and exploit E. tukula germplasm resources, a core collection (containing 34 individuals derived from 10 genetic groups) was first constructed based on phenotypic growth traits and whole-genome resequencing (WGS) data.
View Article and Find Full Text PDF