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Objective: To evaluate factors associated with complications related to the use of peripherally inserted central venous catheters in children undergoing surgical procedures.
Methods: This was a case-control study, conducted in a public hospital in Sorocaba, with an emphasis on surgical procedures, between 2018 and 2022. Electronic medical records were used as a source of information. Odds ratio (OR) and 95% confidence intervals (95%CI) were calculated.
Results: The study included 109 children aged up to 2 years 11 months and 29 days of age, of which 62 were cases and 47 were controls. The frequency of complications related to the use of peripherally inserted central venous catheters was 56.9% (95%CI 47.3; 66.0), and the most frequent complications were obstruction (30.3%) (95%CI 22.3; 39.7), accidental removal (10.1%) and hyperemia (9.2%). There was a greater chance of complications when the child remained in the neonatal pediatric intensive care unit (OR 5.45; 95%CI 1.20; 24.8) and when maintaining intravenous hydration (OR 3.71; 95%CI 1.02; 13.52). Female children (OR 2.93; 95%CI 1.24; 6.91), using total parenteral nutrition (OR 2.97; 95%CI 1.11; 7.94) and with Down syndrome (OR 19.19; 95%CI 2.23; ∞) had a higher chance of obstruction.
Conclusion: Children in intensive care and receiving intravenous hydration had a higher chance of complications. Understanding the factors associated with complications benefits patients, healthcare institutions and the Brazilian Unified Health System (SUS).
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http://dx.doi.org/10.1590/S2237-96222025v34e20240134.en | DOI Listing |
Clin Anat
September 2025
Department of Communication Disorders and Sciences, Rush University Medical Center, Chicago, Illinois, USA.
This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as gleaned from death certificates. HFI is an irregular bony overgrowth of the endocranial surface of the frontal bone.
View Article and Find Full Text PDFProtein Cell
August 2025
Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200433, China.
Cardiovascular disease (CVD) research is hindered by limited comprehensive analyses of plasma proteome across disease subtypes. Here, we systematically investigated the associations between plasma proteins and cardiovascular outcomes in 53,026 UK Biobank participants over a 14-year follow-up. Association analyses identified 3,089 significant associations involving 892 unique protein analytes across 13 CVD outcomes.
View Article and Find Full Text PDFJ Investig Allergol Clin Immunol
September 2025
Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Background And Objectives: Pollen-food allergy syndrome (PFAS) is a frequent comorbidity in individuals with hay fever. Identifying risk factors and allergen clusters can aid targeted interventions and management strategies. Objective: This study characterizes PFAS in patients with hay fever and identifies associated risk factors using the mobile health platform, AllerSearch.
View Article and Find Full Text PDFExp Ther Med
October 2025
Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Immune-related factors may serve an important role in the development of endometriosis, considering the occurrence of substantial abnormalities in the immune system of women with endometriosis, including reduced T-cell reactivity and natural killer cell cytotoxicity, as well as increased numbers and activation of peritoneal macrophages. Moreover, women suffering from endometriosis are at a higher risk for developing various autoimmune diseases as comorbidities of endometriosis. Recent epidemiological data demonstrate that patients with endometriosis have a significantly higher risk (2.
View Article and Find Full Text PDFEur J Case Rep Intern Med
August 2025
Nephrology Department, Unidade Local de Saúde de Braga, Braga, Portugal.
Introduction: Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF) and is widely used in oncology for its anti-angiogenic properties. However, VEGF inhibition may result in significant nephrotoxicity, including thrombotic microangiopathy (TMA). While systemic TMA is well-described, isolated renal-limited TMA remains under recognised.
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