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Background: Painful spasticity in the shoulder is a debilitating condition that significantly impairs quality of life. Conservative treatments often fail to provide adequate relief, leaving patients with limited therapeutic options.
Case Report: A retrospective study was conducted on 8 patients treated with the permanent Freedom® Peripheral Nerve Stimulator (PNS) System at the suprascapular nerve (SN) for painful shoulder spasticity. At baseline, patients reported a mean pain score of 7.6 ± 1.6. Following the trial phase, pain scores decreased to 2.9 ± 1.9 (62%; P < 0.001). At 3 months, the mean pain score was 3.2 ± 1.9 (58%; P < 0.001). Patient satisfaction was high, with 88% recommending the system and considering additional implants for other nerve targets. No adverse events were observed.
Conclusions: The Curonix Freedom PNS System, targeting the SN, is an effective and safe therapy for treating chronic shoulder pain with spasticity, resistant to conservative therapy.
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Wounds
August 2025
Faculty of Physical Therapy, Cairo University, Cairo, Giza, Egypt.
Background: Charcot foot is a debilitating complication of peripheral neuropathy and is primarily associated with diabetes, leading to structural damage, ulceration, and osteomyelitis. Pulsed electromagnetic field (PEMF) therapy is a promising treatment modality for wound healing and bone metabolism.
Objective: To evaluate the efficacy of PEMF therapy in promoting bone growth and ulcer healing in patients with Charcot foot ulcers.
Surg Radiol Anat
September 2025
Department of Anatomy, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Purpose: This study aims to evaluate the morphological features of the levator palpebrae superioris muscle (LPS) and the variations in the distribution of the oculomotor nerve in the muscle.
Methods: 100 bilateral orbits from 50 cadavers were included in our study. In our study, the medial, lateral, and middle length, width, and thickness of the LPS were measured from 3 different points and recorded.
Nature
September 2025
Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Neural activity is increasingly recognized as a crucial regulator of cancer growth. In the brain, neuronal activity robustly influences glioma growth through paracrine mechanisms and by electrochemical integration of malignant cells into neural circuitry via neuron-to-glioma synapses. Outside of the central nervous system, innervation of tumours such as prostate, head and neck, breast, pancreatic, and gastrointestinal cancers by peripheral nerves similarly regulates cancer progression.
View Article and Find Full Text PDFBiol Pharm Bull
September 2025
Computational and Biological Learning Laboratory, University of Cambridge, Cambridge CB21PZ, United Kingdom.
Neuroimaging in rodents holds promise for advancing our understanding of the central nervous system (CNS) mechanisms that underlie chronic pain. Employing two established, but pathophysiologically distinct rodent models of chronic pain, the aim of the present study was to characterize chronic pain-related functional changes with resting-state functional magnetic resonance imaging (fMRI). In Experiment 1, we report findings from Lewis rats 3 weeks after Complete Freund's adjuvant (CFA) injection into the knee joint (n = 16) compared with the controls (n = 14).
View Article and Find Full Text PDFBMJ Case Rep
September 2025
Division of Neurology, Department of Internal Medicine, Nihon University School of Medicine, Itabashi, Tokyo, Japan.
Eosinophilic granulomatosis with polyangiitis (EGPA) and bullous pemphigoid (BP) are both autoimmune diseases characterised by eosinophilic involvement. Coexistence of the two diseases is rare, and confirmatory immunological analyses for BP are lacking in such cases. Here, we report a male in his 80s diagnosed with EGPA 5 years previously who developed numbness and tense blisters but showed no peripheral eosinophilia.
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