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Aldosterone synthase inhibition: a novel bullet to fight cardiovascular-kidney metabolic syndrome.
J Mol Endocrinol
September 2025
INSERM, UMRS 1166, Hôpital La Pitié Salpetriere, Sorbonne Université, Paris, France.
Aldosterone is synthesized by the CYP11B2 enzyme, primarily in the zona glomerulosa of the adrenal gland. It exerts its classical effects on sodium and water balance in the renal distal nephron through binding to the mineralocorticoid receptor (MR). Excess aldosterone production or overactivation of the MR outside the distal nephron leads to cardiac, renal, and vascular injury by increasing oxidative stress and activating the inflammatory and fibrotic pathways.
View Article and Find Full Text PDF[Paraneoplastic rhabdomyolysis].
Inn Med (Heidelb)
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Klinik für Allgemeine Innere Medizin und Altersmedizin, Evangelisches Klinikum Köln Weyertal, Weyertal 76, 50931, Köln, Deutschland.
A 49-year-old female patient presented with decline of general health and muscle pain. Laboratory findings showed a combination of rhabdomyolysis and severe hypokalemia. Symptoms improved with potassium supplementation.
View Article and Find Full Text PDFClinical Utility of Salivary Steroid Profiling for the Differential Diagnosis of Adrenal Diseases.
J Clin Endocrinol Metab
September 2025
Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine.
Context: Although salivary steroid sampling offers several advantages, the diagnostic potential of salivary steroid metabolites remains largely unexplored.Objective To evaluate the diagnostic utility of salivary steroid profiling in patients with adrenal diseases.
Design: Prospective multicenter study.
Primary Aldosteronism: Ubiquitous, Yet Unrecognized.
J Am Coll Cardiol
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Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
Rethinking Primary Aldosteronism: The 2025 John H. Laragh Research Award.
Am J Hypertens
September 2025
Department of Medicine, Division of Endocrinology and Metabolism, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Dr John Laragh, a pioneer in the field of hypertension, held a fundamental belief in the need to challenge existing dogmas in medicine to enhance our scientific understanding of disease and advance patient care. Perhaps in no area of hypertension does this ring truer with than primary aldosteronism (PA). Following its initial description in the mid-1950s with an initial surge in diagnoses soon thereafter, PA was ultimately relegated to be considered a "zebra" of hypertension felt to be responsible for only a small percentage of cases.
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