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Unlabelled: Nasal glial heterotopia (nasal glioma) is a rare congenital benign accumulation of glial tissue displaced into the nasal cavity or paranasal sinuses.
Objective: To analyze our own clinical cases of nasal glioma (features of the clinic, diagnosis and treatment) and compare them with data from foreign literature.
Material And Methods: A retrospective review of medical histories with a diagnosis of nasal glial heterotopia was conducted from 2017 to November 2023 at the pediatric otorhinolaryngological department of the National Medical Research Center for Otorhinolaryngology. Complaints, anamnesis data, the results of radiation diagnosis and the effectiveness of the treatment were analyzed.
Result: Over the past 6 years, 7 patients with a diagnosis of nasal glial heterotopia have been treated in the Department of Pediatric otorhinolaryngology, the average age is 3 years and 8 months ± 3 years and 3 months. Nasal glioma was most often located subcutaneously in 1 patient (14,%), mixed in 1 patient (14.5%), intranasally in 5 patients (71%), in the middle line in 2 patients (14.5%), on the right in 2 patients (28.6%), on the left in 3 patients (42.8%). All patients underwent surgical treatment. External access was used in 1 patient (14.5%), endonasal access was used in 5 patients (71%), and combined access was used in 1 patient (14.5%). Relapses after surgical treatment were not observed in any of the patients from 6 months to 5 years (on average 3 years).
Conclusion: Nasal glial heterotopia is a rare congenital pathology. Preoperative examination of the patient is an important moment for determining the preliminary diagnosis, as well as choosing surgical access and for deciding whether to involve a neurosurgeon.
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http://dx.doi.org/10.17116/otorino20259004158 | DOI Listing |
Vestn Otorinolaringol
September 2025
National Medical Research Center for Otorhinolaryngology, Moscow, Russia.
Unlabelled: Nasal glial heterotopia (nasal glioma) is a rare congenital benign accumulation of glial tissue displaced into the nasal cavity or paranasal sinuses.
Objective: To analyze our own clinical cases of nasal glioma (features of the clinic, diagnosis and treatment) and compare them with data from foreign literature.
Material And Methods: A retrospective review of medical histories with a diagnosis of nasal glial heterotopia was conducted from 2017 to November 2023 at the pediatric otorhinolaryngological department of the National Medical Research Center for Otorhinolaryngology.
Cureus
July 2025
Pediatric Otolaryngology, Joe Dimaggio Children's Hospital, Hollywood, USA.
This case is that of a two-day-old male patient born full term with no pertinent history who presented with excess nasal secretions, feeding difficulty, respiratory distress, and hypoxemia requiring intubation. He was found to have an obstructive, polypoid mass in the nasopharynx on fiberoptic flexible laryngoscopy. Magnetic resonance imaging (MRI) of the brain and neck revealed an ovoid, circumscribed, peripherally enhancing mass in the posterior nasopharynx and oral cavity measuring 2.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Addis Ababa university college of health science, Department of Pathology, Addis Ababa, Ethiopia.
Introduction And Importance: Glial heterotopia (GH) is a rare congenital lesion characterized by the presence of normal glial tissue in extracranial sites with no connection to the central nervous system. Oropharyngeal occurrence is very rare. The aim of this case report is to emphasize that oropharyngeal glial heterotopia can present as a large mass causing airway obstruction.
View Article and Find Full Text PDFJ Neuropathol Exp Neurol
September 2025
Sudha Gopalakrishnan Brain Centre, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
Holoprosencephaly (HPE) is a well-described forebrain patterning disorder in mid-late gestation fetuses and infants. Here, we used a novel, whole-brain multimodal approach (ultrasonography, magnetic resonance imaging, and histology with 3-dimensional [3D] reconstructions with cell mapping) in earlier-gestation specimens than previously reported. In one 13- and two 22-gestational week fetuses and age-matched controls, we elucidated heretofore underappreciated HPE findings of (1) abnormal clustering of immature (doublecortin-immunoreactive) cells in the midline and paramedian forebrain, (2) linear arrays of cells in the intermediate zone of the cerebral mantle (reminiscent of subcortical band heterotopia, but possibly transient), (3) "reactive"-appearing glial fibrillary acidic protein-immunoreactive cortical cells, and (4) apparent "midline fusion" of rostral ganglionic eminences.
View Article and Find Full Text PDFEpilepsia
August 2025
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Objective: Phosphorylated tau (pTau) has been reported in surgical resections in refractory epilepsy. It is unclear whether this is activity-driven physiological pTau or signifies the advent of neurodegenerative cascades, relevant to memory decline. To date, primarily hippocampal sclerosis and focal cortical dysplasia (FCD) type II have been studied.
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