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Quantum dots (QDs) have garnered significant attention for their unique size-dependent optical and electronic properties, enabling their widespread use in applications ranging from high-efficiency photovoltaics and light-emitting diodes to biomedical imaging and quantum computing. Their tunable emission, high photo-stability, and ease of surface modification make them ideal candidates for precision nanotechnology applications. In this work, we explore a novel and rapidly emerging application of QDs in hardware security through the development of Quantum Dot-based Physical Unclonable Functions (QD-PUFs). Unlike conventional security paradigms, QD-PUFs leverage the intrinsic physical randomness of QD-based nanostructures to generate challenge-response pairs with superior uniqueness, reliability, and robustness. We review the integration of QDs into PUFs, beginning with their material properties and extending to entropy sources arising from synthesis and fabrication, surface and encapsulation effects. A comparative analysis of different readout mechanisms and related applications underscores the unique encoding capacity and security potential of QD-based systems. By demonstrating their feasibility for scalable, high-security applications, this study underscores the transformative impact of QDs in next-generation authentication and anti-counterfeiting technologies.
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http://dx.doi.org/10.1039/d5nr03356j | DOI Listing |
Nanoscale Adv
August 2025
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research S.A.S. Nagar Mohali 160062 Punjab India
Nitrosamines are genotoxic, mutagenic impurities and are widely encountered in the global landscape of the pharmaceutical industry. There is a need for rapid detection of nitrosamines in a pharmaceutical product. Here, we report the synthesis of carbon quantum dots (CQDs) using a readily available carbon precursor.
View Article and Find Full Text PDFNanoscale
September 2025
Department of Materials Science and Engineering, Indian Institute of Technology Delhi, New Delhi 110016, India.
Quantum dots (QDs) have garnered significant attention for their unique size-dependent optical and electronic properties, enabling their widespread use in applications ranging from high-efficiency photovoltaics and light-emitting diodes to biomedical imaging and quantum computing. Their tunable emission, high photo-stability, and ease of surface modification make them ideal candidates for precision nanotechnology applications. In this work, we explore a novel and rapidly emerging application of QDs in hardware security through the development of Quantum Dot-based Physical Unclonable Functions (QD-PUFs).
View Article and Find Full Text PDFGels
August 2025
Research Center of Henan Provincial Agricultural Biomass Resource Engineering and Technology, College of Life Science, Nanyang Normal University, Nanyang 473061, China.
Elevated levels of homocysteine (Hcy) are associated with various pathological conditions including atherosclerosis, hypertension, and cardiovascular diseases. In this work, quantum-dot-based molecularly imprinted hydrogels (QD@MIHs) were developed by integrating L-cysteine-modified ZnS quantum dots (QDs)with highly selective molecular imprinting technology for rapid homocysteine detection. The QD@MIPHs were fabricated using a dual-functional monomer system (acrylamide and methacrylic acid) through surface coating of the Hcy molecularly imprinted polymer gel onto the QDs.
View Article and Find Full Text PDFAnal Biochem
August 2025
Pharmaceutical Analysis Research Center, Pharmaceutical Sciences Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Carbamazepine is a widely prescribed antiepileptic drug with a narrow therapeutic index, necessitating precise monitoring to avoid toxicity and ensure therapeutic efficacy. This study presents a fluorescence-based nanosensor using boron nitride quantum dots (BNQDs) for the rapid and sensitive detection of carbamazepine in exhaled breath condensate (EBC). BNQDs were prepared via a simple hydrothermal technique and characterized using transmission electron microscopy, dynamic light scattering, energy-dispersive X-ray, and attenuated total reflectance-Fourier transform infrared techniques.
View Article and Find Full Text PDFJ Fluoresc
August 2025
Nanohmics Inc, 6201 E. Oltorf Street Suite 400, Austin, TX, 78741, USA.
The use of highly fluorescent quantum dot labels in lateral flow test strips enhances sensitivity of these rapid, facile and popular handheld diagnostic devices over traditional colloidal gold or latex particle labels. In this work, we demonstrate apparent detection limits of 1.25 ppb (ng/ml) for the important foodborne biotoxin staphylococcal enterotoxin B (SEB) in chicken rinsate and 78 ppb (ng/ml) in whole milk both by visual and objective fluorometer readings with optimized lateral flow (LF) red quantum dot-based test strips in 15 min.
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