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In this systematic review, we provide a summary of the current knowledge and understanding of escalation crossover offenders who transition from online to subsequent contact child sexual offenses. A systematic search of 14 databases was conducted to identify literature relevant to escalation crossover offenders. Thirty-two studies met the inclusion criteria. Findings reveal different profiles of escalation crossover from child sexual exploitation material (CSEM) offending, online solicitation (OS) offending, and commercial offending. Risk factors and characteristics of CSEM escalation crossover offenders included age, prior criminal history, sexual inclination toward children, cognitive distortions, severity, extremity, and frequency of CSEM engagement, communicating or attempting to communicate with children, and networking with other CSEM offenders. Risk factors and characteristics of OS escalation crossover offenders included race, age, marital/relationship status, employment status, education level, sexual inclination toward children, cognitive distortions, psychiatric disorders, and prior criminal history. Risk factors and characteristics of commercial escalation crossover offenders included race, age, employment status, marital/relationship status, and denying a history of contact offending. Behavioral themes were also identified for OS and commercial escalation crossover offenders. Findings and future directions are discussed in relation to practical, policy, and research implications.
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http://dx.doi.org/10.1177/15248380251361065 | DOI Listing |
Trauma Violence Abuse
September 2025
University of Canberra, ACT, Australia.
In this systematic review, we provide a summary of the current knowledge and understanding of escalation crossover offenders who transition from online to subsequent contact child sexual offenses. A systematic search of 14 databases was conducted to identify literature relevant to escalation crossover offenders. Thirty-two studies met the inclusion criteria.
View Article and Find Full Text PDFNeuropsychopharmacology
August 2025
Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Methamphetamine is a widely abused drug, and its chronic use is associated with significant negative physical and mental health consequences. Individual differences in subjective responses to acute methamphetamine have been previously linked to vulnerability for future misuse. However, the neural mechanisms underlying these individual differences remain poorly understood, particularly at the functional connectome level.
View Article and Find Full Text PDFDiabetes Obes Metab
October 2025
Huadong Global Innovative Development Center, Hangzhou Zhongmei Huadong Pharmaceutical Company, Hangzhou, Zhejiang, China.
Aims: To evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single oral doses of HDM1002 in healthy adult participants.
Materials And Methods: This was a first-in-human, randomized, double-blind, placebo-controlled, 2-part study. Healthy participants aged 18 to 55 years with a body mass index (BMI) of 19.
ESC Heart Fail
July 2025
From the Heart Failure Unit, Department of Cardiology, Rambam Health Care Campus, Haifa, Israel.
Aims: Oral diuretic treatment has limited efficacy in managing chronic heart failure (HF) patients. Novel strategies are needed to manage patients with refractory congestion despite optimal HF therapy and high-dose oral diuretic treatment. In the present study, we prospectively quantified the efficacy and safety of an ambulatory, weekly, high-dose parenteral diuresis strategy.
View Article and Find Full Text PDFRespir Care
July 2025
Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Pediatric critical asthma is one of the most frequent reasons for presentation to the emergency department and admission to the floor or pediatric ICU (PICU) in pediatric patients. Clinical pathways and protocols have been used frequently in respiratory care, and many have been associated with an improvement in outcomes. We performed a systematic review on the use of protocols or pathways in the treatment of critical asthma.
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