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http://dx.doi.org/10.1093/brain/awaf323 | DOI Listing |
Rev Cardiovasc Med
August 2025
Department of Cardiovascular Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, 030032 Taiyuan, Shanxi, China.
The AMP-activated protein kinase (AMPK) alpha (AMPK) subunit is the catalytic subunit in the AMPK complex and includes both 1 and 2 isoforms. Phosphorylation of upstream kinases at the Thr172 site in the -subunit is critical for AMPK activation. The kinases upstream of AMPK include liver kinase B1 (LKB1), calcium/calmodulin-dependent protein kinase kinase (CaMKK), and transforming growth factor -activated kinase 1 (TAK1).
View Article and Find Full Text PDFAllergol Immunopathol (Madr)
September 2025
Department of Pediatrics, Ankang Hospital of Traditional Chinese Medicine, Ankang, China;
Allergic asthma is an inflammatory airway disease influenced by genetic and environmental factors and orchestrated by imbalance between T helper 1 cell (Th1) and two immune responses. Inflammation contributes to pathological changes and remodeling in tissues such as the vascular, lung, heart, and beds. The purpose for this study was to evaluate the effects of allergic asthma on heart pathology and remodeling.
View Article and Find Full Text PDFCureus
August 2025
Medicine and Surgery, Peoples University of Medical and Health Sciences, Nawabshah, PAK.
The advancement of science and technology is an undeniable phenomenon that is progressively transforming all aspects of human life, including scientific, social, humanitarian, and environmental fields, among others. Facial reconstruction surgery has recently gained much attention owing to the incorporation of new technologies, such as bioprinting, regenerative medicine (RM), and artificial intelligence (AI) in surgery. These advancements have led to more innovative, site-specific, and optimal methods of addressing the challenges of facial reconstruction following trauma, congenital malformations, and oncological resections.
View Article and Find Full Text PDFArch Esp Urol
August 2025
Department of Nephrology, The Fourth Hospital of Changzhou, 231002 Changzhou, Jiangsu, China.
Objective: To explore the impact of Tripterygium wilfordii glycosides (TWG) on glomerulosclerosis within a rat model of chronic kidney disease (CKD), as well as the role of the transforming growth factor-β1 (TGF-β1)/Smad signaling pathway in this mechanism.
Methods: Twenty-four clean Sprague-Dawley rats were divided into Sham group (n = 8), model group (n = 8) and TWG group (n = 8). Adriamycin nephropathy (ADRN) rat model was established by jugular vein injection of adriamycin (ADR).
Medicine (Baltimore)
September 2025
Department of Orthopedic Surgery, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, China.
The purpose of this study was to investigate potential therapeutic targets for osteosarcoma (OS) and offer hints regarding genetic factors for OS treatment using a bioinformatics method. This study processed 3 OS datasets from the gene expression omnibus database using R software, screening for differentially expressed genes (DEGs). After enrichment analysis, based on expression quantitative trait loci data and the genome-wide association study data of OS, Mendelian randomization analysis was used to screen the genes closely related to OS disease, which intersect with DEGs to obtain co-expressed genes, validation datasets were employed to verify the results.
View Article and Find Full Text PDF