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Objective: Adverse experiences during childhood (ACEs) and other adversities, such as experiences of discrimination are important risk factors for substance use, particularly among Black individuals in the United States (U.S.). Given the ethnic diversity of Black people in the U.S., it is important to examine how nativity influences the impact of these stressors on substance use risk.
Methods: Participants were 484 Black young adults (YA) recruited through opt-in panels and online platforms. Nativity differences in the association between ACEs, everyday discrimination, and count of tobacco/nicotine and cannabis products used were examined with descriptive statistics, zero-inflated negative binomial (ZINB), and logistic regression models.
Results: Participants' average age was 21.96 years; 53.1% females and 37.6% foreign-born. There were nativity differences ( < 0.05) in education, ACEs, everyday discrimination and lifetime count of tobacco/nicotine and cannabis product types used. Each additional ACE and experience of everyday discrimination was associated with higher lifetime tobacco/nicotine product count by 5% (IRR = 1.05, 95% CI 1.01-1.09) and 2% (IRR = 1.02, 95% CI 1.01-1.04), respectively. ACEs were associated with lower odds of abstaining from tobacco/nicotine and cannabis products in the lifetime (aOR = 0.87, 95% CI 0.76-0.99 and aOR = 0.83 95% CI 0.73-0.95, respectively) and higher odds of co-occurring product exposure (aOR = 1.17, 95% CI 1.05-1.31). Foreign-born YA had 40% lower cannabis product count (IRR = 0.60, 95% CI 0.41-0.88) relative to U.S.-born YA.
Conclusion: Findings emphasize the role of early life (ACEs) and societal stressors (everyday discrimination) on tobacco/nicotine and cannabis product count (i.e., exposure) among U.S.- and foreign-born Black YA.
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http://dx.doi.org/10.1080/10826084.2025.2549786 | DOI Listing |
Lancet Rheumatol
September 2025
Academic Rheumatology, University of Nottingham, Nottingham, UK.
Background: Allopurinol, the most prescribed urate-lowering drug, is a known cause of severe cutaneous adverse reactions. We aimed to develop and validate a model to assess the risk of allopurinol-induced severe cutaneous adverse reactions in adults newly prescribed allopurinol.
Methods: In this retrospective new-user cohort study, we developed and validated a prognostic model using primary care, hospitalisation, and mortality data extracted from the UK Clinical Practice Research Datalink (CPRD) primary care database, for the period Jan 1, 2001, to March 29, 2021.
Arch Med Res
September 2025
Department of Hematology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. Electronic address:
Objective: A subset of patients with multiple myeloma (MM) experience early relapse despite the absence of any high-risk features at diagnosis, defined as functional high-risk (FHR) MM with inferior prognosis. This study compared FHR and standard risk (SR) MM cohorts to investigate clinical risk factors and establish a validated prognostic model for early prediction of FHR in patients with MM that were transplanted.
Methods: A retrospective cohort study was conducted to analyze the clinical data of patients with MM.
Ann Plast Surg
September 2025
From the Department of Plastic Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Background: Burns are associated with significant morbidity and mortality, with several factors determining mortality. Identifying reliable early predictors of mortality is crucial for guiding treatment decisions and improving outcomes. This study evaluates the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting mortality in patients with severe burns.
View Article and Find Full Text PDFEthnic identity refers to how individuals perceive and experience themselves in the context of social groups, racial background, or culture (Phinney & Ong., 2007). Ethnic identity is positively associated with psychological well-being (Rivas-Drake et al.
View Article and Find Full Text PDFJ Marital Fam Ther
October 2025
Human Development and Family Science, Syracuse University, Syracuse, New York, USA.
Dating apps have revolutionized the way people seek romantic connections, boasting a staggering 320 million users worldwide. An estimated 20%-40% of adults in the United States reported meeting their romantic partners online. While online dating research has become more popular, little attention has been paid to the experiences of racially and ethnically minoritized (REM) individuals and the unique obstacles they encounter.
View Article and Find Full Text PDF