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Tobacco use, including the increasingly popular hookah smoking, remains a significant global health concern. Despite its growing appeal, especially among young people, hookah smoking has been associated with an increased risk of various cardiovascular diseases (CVD). To explore the associations between demographic and behavioral factors and perceived susceptibility to and severity of cardiovascular diseases ; myocardial infarction (MI), stroke, and hypertension (HTN); a convenience sample of 245 current and former hookah users from Southwest Iran was recruited. Participants completed measures assessing hookah smoking risk perception, stage of change, attitudes and beliefs about hookah use along with demographic information.The Health Belief Model was used to assess participants' perceptions, and cluster analysis was employed to identify homogeneous groups of participants. Chi-square and Kruskal-Wallis tests were applied to examine the associations between the identified groups and various demographic and behavioral factors. The average age of the study participants was 28.9 years (SD = 9.2), with 81.2% being male. Participants perceived HTN as the most likely cardiovascular disease and MI as the most severe. Notably, perceived severity consistently outweighed perceived susceptibility across all three cardiovascular diseases (p < 0.05). Cluster analysis identified six distinct groups based on perceived susceptibility and severity. Individuals in Cluster 6, characterized by moderate susceptibility and high severity, were older and less frequent hookah users compared to those in Cluster 1, who exhibited low susceptibility and low severity. Interestingly, those in Cluster 6 showed a significantly higher willingness to quit hookah use (p < 0.001). The findings indicate that individuals who perceive a higher risk of developing cardiovascular diseases are more likely to consider quitting hookah use. However, most participants in this study demonstrated low perceived susceptibility and severity, suggesting that they may be unaware of the potential adverse health consequences associated with hookah use. To effectively address this issue, comprehensive public health interventions are needed to raise awareness about the addictive nature of hookah, the increased risk of cardiovascular diseases, and the potential for reduced life expectancy and disability are necessary.
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http://dx.doi.org/10.1038/s41598-025-16206-y | DOI Listing |
J Cardiovasc Electrophysiol
September 2025
Department of Internal Medicine, Division of Cardiology, American University of Beirut Medical Center, Beirut, Lebanon.
Eur J Med Res
September 2025
Department of Zoology, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that regulate gene expression in response to metabolic, hormonal, and environmental signals. These receptors play a critical role in metabolic homeostasis, inflammation, immune function, and disease pathogenesis, positioning them as key therapeutic targets. This review explores the mechanistic roles of NRs such as PPARs, FXR, LXR, and thyroid hormone receptors (THRs) in regulating lipid and glucose metabolism, energy expenditure, cardiovascular health, and neurodegeneration.
View Article and Find Full Text PDFSubst Abuse Treat Prev Policy
September 2025
Centre for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany.
Background: Alcohol use disorder (AUD) is conceptualized as a dimensional phenomenon in the DSM-5, but electronic health records (EHRs) rely on binary AUD definitions according to the ICD-10. The present study classifies AUD severity levels using EHR data and tests whether increasing AUD severity levels are linked with increased comorbidity.
Methods: Billing data from two German statutory health insurance companies in Hamburg included n = 21,954 adults diagnosed with alcohol-specific conditions between 2017 and 2021.
Catheter Cardiovasc Interv
September 2025
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Patent foramen ovale (PFO) has been identified as a potential risk factor for cryptogenic stroke (CS). Although transesophageal echocardiography (TEE) is considered the gold standard for PFO detection, false-negative results remain a clinical concern, particularly in CS patients with high suspicion of PFO-related etiology.
Aims: To evaluate the clinical utility of transcatheter PFO exploration (TPFOE) in CS patients with negative TEE findings but high suspicion of PFO-related etiology.
Ren Fail
December 2025
Department of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.
Purpose: This study aimed to investigate the association between body roundness index (BRI) and deaths from all causes and cardiovascular disease (CVD) in participants with chronic kidney disease (CKD).
Materials And Methods: The data was sourced from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Cox proportional hazards regression along with restricted cubic splines were applied to assess the associations of BRI with deaths from all causes and CVD in individuals with CKD.