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Although the traditional Sarma method considers the hydrostatic pressure effect, in the actual engineering, the hydraulic conditions are complex and most of them are nonhomogeneous hydraulic boundary conditions, this paper considers the nonhomogeneous hydraulic boundary conditions based on the traditional Sarma method, and based on the improved Sarma method model, the stability evaluation of the designed slope and the slope angle is carried out with the slope of the Aynak open-pit copper mine as the engineering background-optimization study. Firstly, the numerical simulation method carried out the stability analysis of the designed excavation slopes. Then the stability of the final boundary slopes was evaluated based on the improved Sarma method model. The optimization of the final boundary slope angle was carried out by combining the traditional classical limit equilibrium theory and the improved Sarma method model under the conclusion that the originally designed slopes were more stable. The optimal slope angle suitable for the actual working conditions was obtained.
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http://dx.doi.org/10.1038/s41598-025-17972-5 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
Agonist-induced interaction of G protein-coupled receptors (GPCRs) with β-arrestins (βarrs) is a critical mechanism that regulates the spatiotemporal pattern of receptor localization and signaling. While the underlying mechanism governing GPCR-βarr interaction is primarily conserved and involves receptor activation and phosphorylation, there are several examples of receptor-specific fine-tuning of βarr-mediated functional outcomes. Considering the key contribution of conformational plasticity of βarrs in driving receptor-specific functional responses, it is important to develop novel sensors capable of reporting distinct βarr conformations in cellular context.
View Article and Find Full Text PDFEur J Heart Fail
September 2025
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA.
Aims: Obesity is commonly hypothesized to lead to the development of heart failure (HF) in part due to increases in blood volume (BV) and left ventricular (LV) remodelling. Whether adiposity and obesity severity are associated with BV expansion and subsequent LV remodelling in middle-aged individuals at increased risk (IR) prior to the onset of HF is unknown.
Methods And Results: We analysed data from 96 middle-aged (40-64 years) non-obese (25.
Sci Rep
September 2025
Department of Agribusiness and marketing, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh.
This study examines farmers' knowledge, attitude, and practices (KAP) toward the adoption of dairy livestock intervention (DLI) to enhance food and nutrition security (FNS) in the Southern Delta region of Bangladesh. A stratified random sampling technique was used to collect 400 cross-sectional survey data via Qualtrics e-survey software. Data analysis employed descriptive statistics, inferential statistics, and Partial least squares structural equation modelling (PLS-SEM).
View Article and Find Full Text PDFSci Rep
September 2025
School of Resources and Safety Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
Although the traditional Sarma method considers the hydrostatic pressure effect, in the actual engineering, the hydraulic conditions are complex and most of them are nonhomogeneous hydraulic boundary conditions, this paper considers the nonhomogeneous hydraulic boundary conditions based on the traditional Sarma method, and based on the improved Sarma method model, the stability evaluation of the designed slope and the slope angle is carried out with the slope of the Aynak open-pit copper mine as the engineering background-optimization study. Firstly, the numerical simulation method carried out the stability analysis of the designed excavation slopes. Then the stability of the final boundary slopes was evaluated based on the improved Sarma method model.
View Article and Find Full Text PDFFam Pract
August 2025
Department of Epidemiology and Biostatistics, Western University, London, Canada N6G 2M1.
Objective: To conduct a systematic review of the literature on the impact of team-based primary care on downstream health care utilization (all-cause or mental health-specific emergency department (ED) visits and hospitalizations) among people with mental or substance use disorders.
Methods: A literature search was conducted using the Scopus, MEDLINE, and Web of Science databases. Gray literature and forward and backward citation searches yielded additional results.