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Aims: This study examines the impact of sleep quality in patients during the first week after transfer from the intensive care unit on post-intensive care syndrome, as well as the mediating role of fatigue levels.
Design: A cross-sectional design was employed in a hospital in southern Taiwan.
Methods: One hundred twenty-six intensive care unit survivors were included in the analysis. The outcome measures included a post-intensive care syndrome scale, the Brief Fatigue Inventory-Taiwan, and a 10-point analogue scale for sleep quality. Statistical and hierarchical linear regression methods were used.
Results: The mean score for post-intensive care syndrome was 19.9 (SD = 7.6). The mean score for fatigue levels was 40.4 (SD = 15.5), with 93.7% of participants reporting severe fatigue and significant life interference. The mean score for sleep quality was 5.1 (SD = 3.3). The findings indicated that fatigue was a significant predictor of post-intensive care syndrome, accounting for 78.4% of the variances. Furthermore, fatigue served as a complete mediator in the primary relationship examined in this study.
Conclusion: Study results demonstrate that intensive care survivors experience post-intensive care syndrome, which is negatively correlated with sleep quality and positively correlated with fatigue.
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http://dx.doi.org/10.1111/ijn.70047 | DOI Listing |
J Intensive Care
September 2025
German Center for Vertigo and Balance Disorders, Ludwig-Maximilians-Universitat (LMU), University Hospital Grosshadern, Munich, Germany.
Background: Survivors of critical illness frequently face physical, cognitive and psychological impairments after intensive care. Sensorimotor impairments potentially have a negative impact on participation. However, comprehensive understanding of sensorimotor recovery and participation in survivors of critical illness is limited.
View Article and Find Full Text PDFBackground: Patients who have been treated in intensive care units (ICUs) display a multitude of physical, cognitive, and/or mental impairments that are collectively called post-intensive care syndrome (PICS). People with PICS have difficulty returning to everyday life.
Methods: In this narrative review, we present epidemiologic data, risk factors, and approaches to the prevention and treatment of PICS, along with the evidence supporting them.
Am J Respir Cell Mol Biol
September 2025
University of Toronto, Interdepartmental Division of Critical Care Medicine, Toronto, Ontario, Canada.
Post-Intensive Care Syndrome (PICS) is a serious condition involving physical weakness, depression, and cognitive impairment that develop during or after an intensive care unit (ICU) stay, often resulting in long-term declines in quality of life. Patients with acute respiratory distress syndrome (ARDS) and severe COVID-19 are at particularly high risk, yet the molecular mechanisms underlying PICS remain poorly understood. Here, we identify impaired Apelin-APJ signaling as a potential contributor to PICS pathogenesis via disruption of inter-organ homeostasis.
View Article and Find Full Text PDFAcute Crit Care
August 2025
Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
Background: Survivors of critical illness often face significant physical and psychological challenges, including post-traumatic stress disorder (PTSD), anxiety, and depression, which can severely impact their quality of life. This study aimed to evaluate the prevalence and associated factors of PTSD, anxiety, and depression among intensive care unit (ICU) survivors 3 months after discharge, and investigate the prevalence and determinants of post-intensive care syndrome-related neuropsychiatric disorders (PICS-ND).
Methods: This is a prospective observational analytical study carried out in a medical ICU.
Acute Crit Care
August 2025
Division of Disaster and Emergency Medicine, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe, Japan.
Intensive care unit (ICU)-acquired muscle atrophy and weakness are key contributors to post-intensive care syndrome (PICS), which can lead to long-term functional impairments. Although the ICU survival rate has improved, many patients continue to experience persistent functional impairments that hinder their reintegration into society. This review summarizes a series of observational and interventional studies conducted as part of the Muscle Atrophy Zero Project, focusing on the etiology, assessment, and prevention of ICU-acquired muscle atrophy and weakness.
View Article and Find Full Text PDF