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Cervical cancer remains a major health concern in India, despite being preventable through human papillomavirus (HPV) vaccination and routine screening. This review examines the key barriers that prevent early detection and treatment, focusing on healthcare system challenges, sociocultural influences, and economic factors. The findings highlight that many women, especially those from rural and lower-income communities, do not have access to proper screening or vaccination due to a lack of awareness, financial difficulties, and inadequate healthcare facilities. Cultural stigma and misinformation about HPV vaccines further discourage preventive measures. The healthcare system itself faces limitations, including a shortage of trained medical professionals, insufficient screening programs, and delays in diagnosis. Many women are only diagnosed when the disease has already progressed, making treatment less effective. Regional differences also play a role, with some states having better access to care while others struggle with limited resources. To reduce the impact of cervical cancer in India, this review suggests increasing awareness through community-based education programs, integrating HPV vaccines into the national immunization plan, and improving access to screening facilities, especially in rural areas. Training healthcare workers to educate and encourage women to get screened and vaccinated can also lead to better outcomes. Mobile screening units and digital health initiatives can help further reach underserved populations. Future research should focus on evaluating the effectiveness of these interventions, understanding the reasons behind vaccine hesitancy, and exploring new ways to improve healthcare access for women. A coordinated approach involving the government, healthcare providers, and community organizations is necessary to ensure that all women, regardless of their background, have access to life-saving prevention and treatment options.
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http://dx.doi.org/10.7759/cureus.88967 | DOI Listing |
J Pathol Transl Med
September 2025
Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Background: C-C motif chemokine ligand 3 (CCL3) is a crucial chemokine that plays a fundamental role in the immune microenvironment and is closely linked to the development of various cancers. Despite its importance, there is limited research regarding the expression and function of CCL3 in nasopharyngeal carcinoma (NPC). Therefore, this study seeks to examine the expression of CCL3 and assess its clinical significance in NPC using bioinformatics analysis and experiments.
View Article and Find Full Text PDFObstet Gynecol Sci
September 2025
Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea.
Objective: This study aimed to compare the outcomes of excision (conization) and active surveillance in women under 35 years of age diagnosed with cervical intraepithelial neoplasia 2 (CIN 2) on disease regression to normal cervical cytology and the effectiveness of nonsurgical management.
Methods: This retrospective cohort study was conducted at OOO. Women under 35 diagnosed with CIN 2 were included and divided into two groups based on the management strategy: excisional treatment or active surveillance.
Lab Chip
September 2025
Department of Engineering Design, Indian Institute of Technology Madras, India.
Microfluidic devices offer more accurate fluid flow control and lower reagent use for uniform nanoparticle synthesis than batch synthesis. Here, we propose a microfluidic device that synthesizes uniform iron oxide nanoparticles (IONPs) for highly efficient intracellular delivery. The 3D-printed device was fabricated, comprising two inlets in the T-shaped channel with an inner diameter of 2 mm, followed by a helical mixing channel with a single outlet.
View Article and Find Full Text PDFJ Med Virol
September 2025
Department of Gynaecology, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong, China.
Persistent high-risk human papillomavirus (HPV) infection is a leading cause of cervical cancer worldwide. While prophylactic vaccines exist, many women remain at risk due to prior exposure or limited access to vaccination. Current treatments focus on ablating visible lesions but often fail to clear the virus completely.
View Article and Find Full Text PDFCurr Cancer Drug Targets
September 2025
Department of Biotechnology, Institute of Applied Sciences &Humanities, GLA University, 17km Stone, NH-19, Mathura, Delhi Road, P.O. Chaumuhan, Mathura, 281 406, U.P. India.
Phospholipids play a crucial role in various aspects of cancer biology, including tumor progression, metastasis, and cell survival. Recent studies have highlighted the signifi-cance of phospholipid metabolism and signaling in multiple cancer types, such as breast, cer-vical, prostate, bladder, colorectal, liver, lung, melanoma, mesothelioma, and oral cancer. Al-terations in phospholipid profiles, particularly in phosphatidylcholine and phosphatidylethan-olamine, have been identified as potential biomarkers for cancer diagnosis and prognosis.
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