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Background Artificial intelligence (AI), particularly language models such as ChatGPT, is gaining importance in medical education and knowledge assessment. Previous studies have demonstrated the growing effectiveness of AI in solving medical exams, including the Final Medical Examination (LEK) and Polish State Specialization Exam (PES) in various specialties, raising questions about its usefulness as a tool to support specialist training processes. Objective The aim of this study was to assess the effectiveness of the latest ChatGPT-4o model in solving the PES in ophthalmology. The analysis focused on the accuracy of the answers and the model's declared confidence level to evaluate its potential educational usefulness. Methods The study was based on the official PES ophthalmology exam (Spring 2024), consisting of 120 multiple-choice questions. The ChatGPT-4o model was familiarized with the exam regulations and questions, which were input in Polish. The effectiveness of the answers was assessed based on the Medical Education Center (CEM) answer key, as well as the model's declared confidence level (on a scale of 1 to 5). The questions were divided into clinical and theoretical categories. Data were analyzed statistically using the chi-square test and the Mann-Whitney U test. Results The model provided 94 correct answers (78.3%), exceeding the passing threshold. No significant difference in effectiveness was observed between clinical and non-clinical questions (p = 0.709). The analysis of the confidence level revealed that correct answers were significantly more often provided with higher confidence (p < 0.001), suggesting that the model's self-assessment could be an indicator of answer accuracy. Conclusions ChatGPT-4o demonstrated high effectiveness in the PES ophthalmology exam, confirming the potential of AI in specialist education. The confidence level of answers could serve as a useful tool in assessing the reliability of responses. Despite promising results, expert supervision and further research in various medical fields are necessary before wider implementation of AI models in medical education.
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http://dx.doi.org/10.7759/cureus.88908 | DOI Listing |
Cancer Epidemiol Biomarkers Prev
September 2025
Kangbuk Samsung Hospital, Seoul, Korea (South), Republic of.
Background: Iron metabolism may influence breast cancer development; however, links between iron-related biomarkers and breast cancer remain inconclusive. Given differences in iron status by menopausal status, we examined associations of ferritin and other iron biomarkers, with breast cancer incidence, stratified by menopausal status, in a Korean screening cohort.
Methods: This cohort study included 140,747 Korean women screened for breast cancer from 2011-2020.
Cell Mol Biol (Noisy-le-grand)
September 2025
Department of Public Health, College of Applied Medical Sciences, Qassim University, Buraydah, 51452 P.O. Box 6666, Saudi Arabia.
Foodborne illnesses pose a significant public health threat globally, particularly in Saudi Arabia, where the rapid growth of the food service sector has increased the risk of exposure to multidrug-resistant (MDR) bacteria. Traditional microbiological methods are often time-consuming and may lack precision, highlighting the need for faster and more accurate diagnostic alternatives. In this study, Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) was employed for the rapid and precise identification of bacterial contaminants in ready-to-eat (RTE) foods, alongside an assessment of their antibiotic resistance profiles.
View Article and Find Full Text PDFPediatr Blood Cancer
September 2025
Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Background: The suppressor of tumorigenesis 2 (ST2) has emerged as one of the most promising biomarkers for predicting mortality of acute graft-versus-host disease (aGvHD) when measured at the onset of symptoms, but detailed time course studies are needed to understand the potential of ST2 as a risk marker of both aGvHD and chronic graft-versus-host disease (cGvHD), potentially allowing pre-emptive adjustment of immunosuppressive treatment.
Procedure: We measured ST2 levels in 117 children undergoing standard hematopoietic stem cell transplantation (HSCT) before conditioning and at regular intervals post-HSCT.
Results: ST2 levels were significantly increased from Day +7 in patients developing aGvHD of any grade (no GvHD: 23.
AIDS
September 2025
Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM.
Objective: France provides universal health coverage to all residents, including undocumented migrants. Most transgender women with HIV (TWH) in France are migrants from Latin America. This study aimed to describe the rate of viral suppression among TWH in France and identify structural factors influencing this outcome.
View Article and Find Full Text PDFAm J Hematol
September 2025
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
Lymphoma-associated hemophagocytic lymphohistiocytosis (LA-HLH) is a life-threatening hyperinflammatory syndrome, and hierarchical management based on a prognostic model is important. The endothelial activation and stress index (EASIX) score has demonstrated prognostic utility in recipients of allogeneic stem cell transplantation and chimeric antigen receptor (CAR) T-cell therapy. However, its role in LA-HLH remains unestablished.
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