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Highly myopic strabismus is a progressive form of esotropia and hypotropia. It occurs when the globe axis is elongated due to high myopia, causing the posterior portion of the globe to dislocate between the superior rectus and lateral rectus muscles and prolapse from the muscle cone. This condition is often accompanied by mechanical restrictions of eye movement. If it progresses, the globe may become fixed in an inferomedial position. The most common treatment is uniting the superior and lateral rectus muscle bellies using a suture posterior to the muscle insertions, also known as the Yokoyama procedure. This case report presents the case of a 59-year-old male patient who underwent the Yokoyama procedure. After surgery, the patient experienced severe inflammation and pain during eye movement; however, as the symptoms subsided, diplopia improved, and by the one-month follow-up examination, the pain had completely resolved. In addition, the patient showed a significant angle of exotropia, which spontaneously recovered to the normal position one month after the surgery, accompanied by the resolution of diplopia. When the patient underwent the Yokoyama procedure after seven years of observation following the initial examination, it was found that the patient had exotropia immediately after surgery, but the eye position improved over time, and the patient was eventually able to maintain a normal position. Postoperative magnetic resonance imaging (MRI) showed that the position of the superior rectus and lateral rectus muscles had improved, and the angle of dislocation had also improved. There have been no reports of spontaneous improvement in postoperative exotropia, as in this case, which provides new insights into the possibility of temporary changes in eye position and spontaneous improvement in the treatment of highly myopic strabismus. Additionally, it also prompts reconsideration of the importance and significance of postoperative management.
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http://dx.doi.org/10.7759/cureus.88932 | DOI Listing |
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Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Previous studies have shown that the pre-transplant C-reactive protein (CRP)/platelet ratio (CP ratio) is a predictor of survival. The aim of this multicenter retrospective study was to evaluate the clinical significance of CP ratio in patients with malignant lymphoma (ML) who underwent allogeneic hematopoietic stem cell transplantation (alloHCT). The cohort included patients with ML who underwent first alloHCT from 2007 to 2021.
View Article and Find Full Text PDFFoot Ankle Int
September 2025
Department of Radiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Background: Coronal wedge insoles are commonly prescribed to mitigate musculoskeletal disorders, yet their static-standing kinematic and kinetic effects on lower extremity joints remain insufficiently understood.
Methods: This cross-sectional experimental study included 15 healthy older adults (mean 64.9 ± 6.
Chem Pharm Bull (Tokyo)
September 2025
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Antigen-binding proteins, such as nanobodies, modified with functional small molecules hold great potential for applications including imaging probes, drug conjugates, and localized catalysts. However, traditional chemical labeling methods that randomly target lysine or cysteine residues often produce heterogeneous conjugates with limited reproducibility. Conventional site-specific conjugation approaches, which typically modify only the N- or C-terminus, may also be insufficient to achieve the desired functionalities.
View Article and Find Full Text PDFDrug Metab Pharmacokinet
July 2025
Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Subcutaneous administration is widely used as a clinical administration route for Fc-fusion proteins. However, predicting bioavailability (BA) in humans after subcutaneous administration is challenging due to multiple factors involved in the absorption process. This study aimed to elucidate the impact of degradation on the BA of Fc-fusion proteins.
View Article and Find Full Text PDFJ Opioid Manag
September 2025
Institute of Medicine; Health Services Research and Development Center; Digital Society Division, Center for Cyber Medicine Research, University of Tsukuba, Ibaraki, Japan.
Objective: Thoracic surgery is known to lead to post-operative opioid dependence in countries with high opioid consumption; however, there are limited reports from countries with moderate to low opioid consumption, such as Japan. This study aimed to investigate the prevalence and risk factors for persistent opioid use after thoracic surgery in Japan.
Design: A retrospective cohort study using linked medical claims data from the National Health Insurance in Ibaraki Prefecture, Japan.