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http://dx.doi.org/10.1055/s-0045-1801867 | DOI Listing |
Wound Repair Regen
September 2025
Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
This study aimed to develop an acellular dermal matrix derived from tilapia skin and evaluate its potential as a bioscaffold for skin wound repair. Structural and compositional changes before and after decellularisation were assessed through histological staining, electron microscopy and immunological analysis. The matrix exhibited low immunogenicity, preserved extracellular matrix architecture and retained key bioactive components.
View Article and Find Full Text PDFACS Biomater Sci Eng
September 2025
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.
The development of biomimetic scaffolds that emulate the extracellular matrix (ECM) is critical for advancing cell-based therapies and tissue regeneration. This study reports the formulation of CHyCoGel, a novel injectable, ECM-mimetic hydrogel scaffold composed of chitosan, hyaluronic acid, chondroitin sulfate, and an amphiphilic stabilizer. CHyCoGel addresses key limitations of existing scaffolds, offering improved structural uniformity, injectability, and gelation suitable for cell encapsulation and minimally invasive delivery.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan.
In adult mammals and other highly developed animals, incomplete wound healing, scar formation, and fibrosis occur. No treatment for complete tissue regeneration is currently available. However, in mice, at up to 13 days of gestation, early embryonic wounds regenerate without visible scarring.
View Article and Find Full Text PDFMater Today Bio
October 2025
Radboud University Medical Center, Research Institute for Medical Innovation, Department of Medical BioSciences, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.
Severe scarring is an inevitable consequence of large full-thickness skin wounds, often leading to long-term complications that affect patients' well-being and necessitate extended medical interventions. While autologous split-thickness skin grafts remain the clinical standard for wound treatment, they frequently result in contractures, excessive scarring, and the need for additional corrective procedures. To address these challenges, bioengineered skin substitutes capable of promoting efficient healing while reducing complications are highly desirable.
View Article and Find Full Text PDFInjury
August 2025
Department of Trauma Surgery, University and University Hospital of Zurich, Raemistr. 100, 8091 Zurich, Switzerland; Center for Preclinical Development, University and University Hospital of Zurich, Raemistr. 100, 8091 Zurich, Switzerland. Electronic address:
Background: Critical size bone defects represent a clinical challenge, associated with considerable morbidity, and frequently trigger the requirement of secondary procedure. To fill osseous gaps, multiple steps are required, such as proliferation and differentiation on the cellular level and the building of extracellular matrix. In addition, the osteogenic potential of cell-derived extracellular matrices (CD-ECM) is known to enhance bone healing.
View Article and Find Full Text PDF