98%
921
2 minutes
20
Insulin stability is a critical yet underexplored factor affecting diabetes outcomes in Sub-Saharan Africa (SSA). High ambient temperatures, unreliable refrigeration, and weak regulatory oversight may compromise insulin quality during storage and use. Patients often rely on traditional, non-validated methods that risk potency loss. This commentary highlights the urgent need for real-world studies on insulin stability and sterility in SSA to inform evidence-based practices and improve glycemic control among diabetic patients in resource-limited settings.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12390779 | PMC |
http://dx.doi.org/10.2147/DMSO.S546772 | DOI Listing |
Insect Sci
September 2025
Programa Operativo Moscas, SADER/SENASICA-IICA, Metapa de Domínguez, Chiapas, Mexico.
Anastrepha obliqua, a neotropical pest widely distributed in the Americas, attacks mango and other tropical fruits. In Mexico, it is controlled through integrated pest management, using the Sterile Insect Technique (SIT) as a main component. The applicability of SIT is significantly improved with the use of genetic sexing strains (GSS) that allow the possibility to release exclusively sterile males, the primary component of the technique.
View Article and Find Full Text PDFDrug Deliv Transl Res
September 2025
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan, 333031, India.
Diabetes is a metabolic disorder of increasing global concern. Characterized by constantly elevated levels of glucose, severe β-cell dysfunction, and insulin resistance, it is the cause of a major burden on patients if not managed with therapeutic and lifestyle changes. The human body is slowly developing tolerance to many marketed antidiabetic drugs and the quest for the discovery of newer molecules continues.
View Article and Find Full Text PDFJ Biosci Bioeng
September 2025
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan.
Blood purification using immunoadsorbent columns is a therapeutic strategy for removing pathogenic autoantibodies in autoimmune diseases. Currently available columns have limitations: Trp/Phe columns offer cost-effectiveness and sterilizability, but lack antigen specificity and have limited capacity to remove diverse pathogenic autoantibodies; whereas Protein A/peptide/anti-human IgG columns target all antibodies, regardless of pathogenicity, limiting specificity, and often require sterile production due to low stability under sterilization conditions, except for peptide ligands. Full-length autoantigen-immobilized immunoadsorbent columns have great potential to specifically adsorb targeted autoantibodies, because autoantibodies recognize diverse epitopes that vary among individuals.
View Article and Find Full Text PDFPLoS Genet
September 2025
Department of Molecular and Cellular Biology, University of California Davis, Davis, California, United States of America.
The synaptonemal complex (SC) is a meiosis-specific structure that aligns homologous chromosomes and promotes the repair of meiotic DNA double-strand breaks (DSBs). To investigate how defects in SC formation affect gametogenesis in zebrafish, we analyzed mutations in two genes encoding core SC components: syce2 and sycp1. In syce2 mutants, chromosomes exhibit partial synapsis, primarily at sub-telomeric regions, whereas sycp1 mutant chromosomes display early prophase co-alignment but fail to synapse.
View Article and Find Full Text PDFInt J Pharm
September 2025
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752, Porto Alegre, Rio Grande do Sul 90610-000, Brazil; Laboratório de Nanocarreadores e Impressão 3D em Tecnologia Farmacêutica (Nano3D), Faculdade de Fa
The implementation of 3D printing technologies in clinical settings depends on formulations that are not only printable and compliant with quality standards but also physicochemical stable and reliable under real-use conditions. This study evaluated the in-use and long-term physicochemical and rheological stability of two hydrogel inks developed for semisolid extrusion (SSE) 3D printing: one containing pimobendan (PBD) and the other a placebo. PBD is a poorly water-soluble drug used to treat canine heart failure, whose formulation challenges highlight the potential of personalised drug delivery.
View Article and Find Full Text PDF