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Introduction: Adenoid hypertrophy (AH) is prevalent in 35%-70% of the global pediatric population, leading to airway obstruction and sleep disturbances. Current diagnostic criteria for the adenoid-to-nasopharyngeal (/) ratio lack age-specific adjustments, potentially resulting in diagnostic inaccuracies.
Methods: This retrospective study assessed pediatric outpatients aged 1-12 years who underwent lateral nasopharyngeal radiography. Measurements of adenoid depth (AD), nasopharyngeal depth (ND), and / ratios were recorded, and age-stratified percentiles (P5-P95) were calculated for four distinct age cohorts. The relationships between AD, ND, and / ratios and age were analyzed. Measurements were conducted by two independent radiologists, with any discrepancies adjudicated by a senior expert.
Results: In this investigation involving 2,629 outpatient children aged between 1 and 12 years, the median AD remained consistent at 14-15 mm, whereas ND increased from 21 to 27 mm, resulting in a decrease in the / ratio from 0.68 to 0.56. Pathological hypertrophy was identified in 42% of children aged 1-3 years, compared to 13.7% in those aged 10-12 years, with no significant sex-based differences observed. Age-specific reference ranges showed that both AD and ND increased with age, whereas the / ratio decreased. A positive correlation was found between AD and both ND and the / ratio, while ND exhibited a negative correlation with the / ratio. Significant discrepancies were noted between age-specific / ratio percentiles and the current fixed diagnostic criteria for children aged 1-12 years. The study established percentile-based reference values (P5-P95) for AD, ND, and the / ratio across four pediatric age groups.
Conclusions: This study established percentile-based reference values (P5-P95) for AD, ND, and the / ratio across four pediatric age groups, thereby recommending age-specific diagnostic thresholds for AH in clinical settings.
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http://dx.doi.org/10.3389/fped.2025.1639498 | DOI Listing |
Neurology
October 2025
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
Objectives: Status epilepticus (SE) is a life-threatening neurologic emergency. Although health disparities in epilepsy are well-documented, disparities in SE mortality are not fully understood. This study analyzes mortality trends and demographics in the United States from 1999 through 2020.
View Article and Find Full Text PDFJ Speech Lang Hear Res
September 2025
Department of Communication Sciences & Disorders, Montclair State University, Bloomfield, NJ.
Purpose: Residual speech sound disorder (RSSD) is a high-prevalence condition that can limit children's academic and social participation, with negative consequences for overall well-being. Previous studies have described visual biofeedback as a promising option for RSSD, but results have been inconclusive due to study design limitations and small sample sizes.
Method: In a preregistered randomized controlled trial, 108 children aged 9-15 years with RSSD affecting American English /ɹ/ were randomly assigned to receive treatment incorporating visual biofeedback (subdivided into ultrasound and visual-acoustic types) or a comparison condition of motor-based treatment consistent with current best practices in speech therapy.
Blood
September 2025
University of Illinois at Chicago, Chicago, Illinois, United States.
Hematopoietic stem cells (HSCs) responsible for blood cell production and their bone marrow regulatory niches undergo age-related changes, impacting immune responses and predisposing individuals to hematologic malignancies. Here, we show that the age-related alterations of the megakaryocytic niche and associated downregulation of Platelet Factor 4 (PF4) are pivotal mechanisms driving HSC aging. PF4-deficient mice display several phenotypes reminiscent of accelerated HSC aging, including lymphopenia, increased myeloid output, and DNA damage, mimicking physiologically aged HSCs.
View Article and Find Full Text PDFPLoS Negl Trop Dis
September 2025
Kenya Medical Research Institute (KEMRI)-Wellcome Trust, Kilifi, Kenya.
Tungiasis is a neglected tropical skin disease caused by the sand flea, Tunga penetrans which penetrates the skin causing considerable pain and itching. In this cross-sectional study we aimed to assess its impact on the quality of life of school children in Kenya. School pupils (198) aged 8-14 years with tungiasis were randomly selected and interviewed using a tungiasis-specific quality of life instrument (TLQI).
View Article and Find Full Text PDFPLoS One
September 2025
Department of Developmental Psychology, Tilburg University, Tilburg, The Netherlands.
Background: Children with conduct problems vary considerably in how they respond to behavioral interventions. Although group-based, child-focused programs are increasingly implemented, research still relies on retrospective parent or teacher reports and group-level outcomes. These traditional approaches often obscure individual differences in treatment response and reduce the potential for individualized behavioral support tailored to each child's unique profile.
View Article and Find Full Text PDF