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Extensive keloid formation may develop at the site of healed herpes zoster lesions as a rare Wolf's isotopic response, even in immunocompetent individuals without a medical history of keloid, highlighting the importance of early antiviral therapy to minimize post-herpetic complications.
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http://dx.doi.org/10.1002/ccr3.70826 | DOI Listing |
Front Pharmacol
August 2025
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, China.
Connective tissue growth factor (CTGF) is notably upregulated in scar tissue, making it a promising target for therapeutic intervention. Here, we have designed and screened an antisense oligonucleotide (ASO) that binds specifically to the exon five sequence of CTGF, with particular emphasis on the use of 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) modifications to enhance stability and specificity. experiments demonstrated that both MOE-ASO#1 and LNA-ASO#1 significantly inhibited fibroblast proliferation and extracellular matrix protein expression.
View Article and Find Full Text PDFWound Repair Regen
September 2025
Center for Tissue Engineering, Department of Plastic Surgery, University of California Irvine, Orange, California, USA.
Dipeptidyl-peptidase 4 inhibitors, DPP-4i, are an established antiglycaemic medication for Type 2 Diabetes. There has been a growing interest in DPP-4i's potential to improve wound healing and reduce fibrosis. The purpose of this study is to survey the current literature for applications of DPP-4i in wound healing and scars, and explore their potential outside of glycaemic control.
View Article and Find Full Text PDFMol Med Rep
November 2025
Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Aberrant extracellular matrix (ECM) production by dermal fibroblasts drives fibrotic skin diseases, which has an adverse impact on the lives of patients. Current treatments are limited; therefore, the development of new antifibrotic strategies is necessary. The aim of the present study was to investigate zinc finger 469 (ZNF469) as a potential ECM regulator in skin fibrosis.
View Article and Find Full Text PDFExtensive keloid formation may develop at the site of healed herpes zoster lesions as a rare Wolf's isotopic response, even in immunocompetent individuals without a medical history of keloid, highlighting the importance of early antiviral therapy to minimize post-herpetic complications.
View Article and Find Full Text PDFSci Rep
August 2025
Center of Excellence in Burn and Wound Care, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Keloid is a trauma-induced fibroproliferative condition characterized by excessive extracellular matrix (ECM) deposition and aberrant keloid fibroblast activation, leading to physical, psychological, functional, and cosmetic impairments. This study investigates DNA methylation alterations at Long Interspersed Nuclear Element-1 (LINE-1) and Alu repetitive elements in keloid tissues compared to normal skin tissues. Methylation levels and patterns were analyzed in keloid (n = 38) and normal skin tissues (n = 32).
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