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Article Abstract
The role of induced gene expression is crucial for tissue regeneration. The transient regenerative cellular state that discriminates between missing-tissue and non-missing-tissue injuries remains to be fully elucidated. In this study, we identified a homolog of Platelet-Derived Growth Factor (PDGF), named (), in the planarian . This gene exhibits inducible expression following missing-tissue injury in a back-and-forth manner between muscular cells and stem cells. The dynamic expression of is induced through the elevation of reactive oxygen species (ROS) levels and phosphorylated extracellular signal-regulated kinase (pERK) signaling over short distances. Suppression of expression impairs the regrowth of essential structures, including the intestine and central nervous system. Evidence on the decrease of and at the anterior pole, together with the accumulation of PIWI-1 progenitors, suggests a role of in pole muscular cell differentiation. These findings highlight the significant impact of in orchestrating the behavior of specific cell types by the regional specificity of this gene expression.
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