Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Depressive symptoms (DS) are associated with cardiovascular disease (CVD). Particular clusters of DS, such as the Somatic Depressive symptoms (SDS) are more associated with CVD than others. Endothelial dysfunction (ED), a precursor to CVD, is linked to traditional risk factors: older age, female sex, non-white ethnicity, smoking, high body weight, and mental stress. However, the association between SDS and ED in healthy non-depressed individuals remains unclear. This study aims to investigate the association between SDS and endothelial function in healthy individuals.
Methods: Cross-sectional study included 132 participants aged 18-60 years without CVD (31.1±11.5 y). Endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery. Depressive symptoms were evaluated with the PHQ-9, focusing on somatic symptoms (sleep, fatigue, appetite). Affective depressive symptoms (ADS)-including anhedonia, low self-esteem, and suicidality-and anxiety were analyzed as distinct psychological constructs. Linear and logistic regression models were performed to identify predictors of FMD and ED.
Results: The cluster of SDS was the strongest predictor of lower FMD (β=-0.329, P<0.001), followed by ADS (β=-0.239, P=0.041) and body surface area (β=-0.209, P=0.037). Logistic regression confirmed SDS as the strongest predictor of ED (P=0.001).
Conclusions: SDS are significantly associated with ED, surpassing the other risk factors. The assessment of the somatic cluster may allow the detection of individuals who are at a high risk of developing CVD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/PSY.0000000000001426 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations of frailty and its changes with the risks of depressive symptoms: A multi-cohort study.
Arch Gerontol Geriatr
August 2025
Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, China. Electronic address:
Background: Frailty is a dynamic condition that may affect mental health. This study aimed to investigate the associations of frailty and its changes with the risks of depressive symptoms across multiple regions in aging populations.
Methods: Data were drawn from five cohort studies in the United States, England, Europe, China, and Mexico.
Ecological Momentary Assessment as a Measure of Intervention Change: Evaluation in 4 Digital Mental Health Trials.
J Med Internet Res
September 2025
Center for Healthy Minds and Department of Counseling Psychology, University of Wisconsin-Madison, Madison, WI, United States.
Background: Ecological momentary assessment (EMA) is increasingly being incorporated into intervention studies to acquire a more fine-grained and ecologically valid assessment of change. The added utility of including relatively burdensome EMA measures in a clinical trial hinges on several psychometric assumptions, including that these measure are (1) reliable, (2) related to but not redundant with conventional self-report measures (convergent and discriminant validity), (3) sensitive to intervention-related change, and (4) associated with a clinically relevant criterion of improvement (criterion validity) above conventional self-report measures (incremental validity).
Objective: This study aimed to evaluate the reliability, validity, and sensitivity to change of conventional self-report versus EMA measures of rumination improvement.
Compensatory cognitive training in the schizophrenia spectrum: A pilot study in an outpatient Mexican sample.
Appl Neuropsychol Adult
September 2025
Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México.
Negative symptoms, depression, and cognitive impairments of the schizophrenia spectrum have been associated with difficulties in daily functioning. Compensatory Cognitive Training (CCT) has shown positive effects on cognition, negative symptoms, and functioning in this population. The main objective of this pilot study was to analyze the effects of CCT on cognition and functioning in a group schizophrenia spectrum outpatients in Mexico.
View Article and Find Full Text PDF[Children's brains with gender dysphoria. Effects of hormones and puberty blockers on a developing brain. An ethical approach].
Cuad Bioet
September 2025
Facultad de Farmacia y Nutrición de la Universidad de Navarra, Irunlarrea, 1, 31008 Pamplona.
In recent years, there has been a significant increase in minors with gender dysphoria (GD) seeking transition treatments, including puberty blockers and cross-sex hormones. The developing child's brain exhibits structural and functional differences in children with GD compared to cisgender children, particularly in areas where sex differences exist. Brain development during childhood and adolescence is strongly influenced by sex hormones.
View Article and Find Full Text PDFInflammation and insulin resistance partially mediate the relationship between age at menopause and depression in postmenopausal women: a cross-sectional study of NHANES 2005-2018.
Menopause
September 2025
Department of Anesthesiology and Perioperative Medicine, Medical College of Georgia at Augusta University, Augusta, GA.
Objective: To evaluate depression in postmenopausal women and to explore the relationship between age at menopause, hormone therapy, and depression, while also identifying potential mediators that may explain these associations.
Methods: This cross-sectional study analyzed data from National Health and Nutrition Examination Survey (NHANES) (2005-2020) for women older than 60 years who completed the Patient Health Questionnaire 9 (PHQ-9) depression questionnaire (n=7,027). Exposures included age at menopause and self-reported hormone therapy; the outcome was depression severity (PHQ-9 ≥10).