Particulate matter and exacerbations of chronic obstructive pulmonary disease: analysis of emergency department visits in a low-pollution area.

Emergencias

Grupo de Ingeniería Biomédica, Universidad de Valladolid, Valladolid, España. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Madrid, España. Servicio de Neumología, Hospital Universitario Río Hortega, Valla

Published: June 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Objective: To evaluate the association between particulate matter concentration (PM10 and PM2.5) and the number of emergency department visits for exacerbation of chronic obstructive pulmonary disease (COPD) in a low-pollution area.

Methods: We conducted an ecological study based on emergency department visits for COPD exacerbations. A generalized additive model was used to estimate the relative risk and attributable fraction (AF), adjusting for weather variables. Pollution levels on the day of the visit and the 5 preceding days were considered to assess potential delayed effects of exposure.

Results: A total of 2,045 patients with 5,233 emergency department visits were included. A total of 79.1% of the patients were men. The mean age was 79.5 years (SD, 10.1). The mean concentration of PM2.5 and PM10 was 11.5 µg/m³ and 17.3 µg/m³, respectively. Both emergency visits and particulate matter concentrations showed a seasonalpattern. A significant association was found with exposure occurring 3 days prior (lag -3), with a 5.8% increase in visits for every 10 µg/m³ increase in PM2.5 (AF 5.45%) and a 3.3% increase for PM10 (AF 3.15%). Men and patients older than 75 years showed greater sensitivity to exposure. The impact of particulate matter was more pronounced during the summer months.

Conclusions: Exposure to PM2.5 and PM10 is associated with an increase in emergency department visits for COPD exacerbations, with a particular impact among men, patients older than 75 years, and during the summer season.

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Source
http://dx.doi.org/10.55633/s3me/052.2025DOI Listing

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