Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1002/1873-3468.70151DOI Listing

Publication Analysis

Top Keywords

expression concern
4
concern live-cell
4
live-cell single-molecule
4
single-molecule imaging
4
imaging reveals
4
reveals clathrin
4
clathrin caveolin-1
4
caveolin-1 dependent
4
dependent docking
4
docking smad4
4

Similar Publications

The purpose of this study was to investigate the efficacy and safety of add-on metformin treatment in persons with active epilepsy (a-PWE). This is a single-centric, double-blind, placebo-controlled trial randomised a-PWE (1:1) to receive either metformin (extended-release 500 mg) or matching placebo for 6 months along with background antiseizure medications. Primary outcome was percentage change in seizure frequency/month, and secondary outcomes were 50% responder rate, serum mTOR expression, and serum total antioxidant capacity (TAC), body composition analysis, quality of life (QOL), and safety assessment.

View Article and Find Full Text PDF

Sodium orthovanadate (vanadate), a potent inhibitor of p53, has been shown in earlier work to alleviate total-body irradiation (TBI)-induced hematopoietic syndrome. However, as p53 plays a crucial role in normal spermatogenesis, its suppression may raise concerns about potential adverse effects on male reproductive function. In this study, we investigated whether vanadate exacerbates impairment of male fertility when administered for hematopoietic protection under TBI conditions.

View Article and Find Full Text PDF

Introduction: Artificial intelligence tools show promise in supplementing traditional physician assistant education, particularly in developing clinical reasoning skills. However, limited research exists on custom Generative Pretrained Transformer (GPT) applications in physician assistant (PA) education. This study evaluated student experiences and perceptions of a custom GPT-based clinical reasoning tool.

View Article and Find Full Text PDF

Objective: We evaluated the empirical fit of our model of clinical momentum for older adults with life-limiting illness undergoing unplanned surgery.

Background: Older adults often undergo surgery near the end of life, in contrast to generally stated preferences. Systems forces promoting intervention may produce nonbeneficial treatment despite advances in communication.

View Article and Find Full Text PDF

A myotropic AAV vector combined with skeletal muscle -regulatory elements improve glycogen clearance in mouse models of Pompe disease.

Mol Ther Methods Clin Dev

June 2025

Université Paris-Saclay, University Evry, Inserm, Genethon, Integrare Research Unit UMR_S951, 91000 Evry, France.

Pompe disease is a glycogen storage disorder caused by mutations in the acid α-glucosidase (GAA) gene, leading to reduced GAA activity and glycogen accumulation in heart and skeletal muscles. Enzyme replacement therapy with recombinant GAA, the standard of care for Pompe disease, is limited by poor skeletal muscle distribution and immune responses after repeated administrations. The expression of GAA in muscle with adeno-associated virus (AAV) vectors has shown limitations, mainly the low targeting efficiency and immune responses to the transgene.

View Article and Find Full Text PDF