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| http://dx.doi.org/10.1016/j.jss.2025.07.064 | DOI Listing |
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From critical care to organ preservation: the potential role of hemadsorption in transplantation-a narrative review.
Hepatobiliary Surg Nutr
August 2025
Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Background And Objective: Hemadsorption, a therapeutic modality traditionally used to mitigate cytokine storm in critically ill patients and is now being tested in other medical fields including organ transplantation, especially for organs from extended criteria donors. Such organs are susceptible to ischemia-reperfusion injury (IRI) during transplantation, which is known to release a cascade of innate immune mediators including damage-associated molecular patterns (DAMPs) and cytokines during reperfusion and ultimately leading to graft dysfunction based on the metabolic injury. To address this challenge, early studies have integrated hemadsorption filters into organ perfusion circuits, such as normothermic regional perfusion (NRP) in donors and machine perfusion (MP) of grafts, with the aim to reduce inflammation and improve organ viability.
View Article and Find Full Text PDFResponse Regarding: "Normothermic Machine Perfusion and Liver Transplant Waitlist Times: A Single-Center Matched Cohort Study".
J Surg Res
August 2025
Division of Transplant, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:
Response Regarding: "Normothermic Machine Perfusion and Liver Transplant Waitlist Times: A Single-Center Matched Cohort Study".
J Surg Res
August 2025
Division of Transplant, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:
Systemic Effects of Enzymatic Necrosectomy in Minor Burn Wounds Using NexoBrid.
J Pers Med
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Department of Plastic, Reconstructive and Hand Surgery, Burn Unit, Paracelsus Medical University, Klinikum Nürnberg, Breslauer Str. 201, 90471 Nuremberg, Germany.
Enzymatic debridement with NexoBrid is an effective alternative to surgical debridement in burn care, but its potential systemic effects remain unclear. In the context of personalized burn care, understanding individual patient responses to topical agents is essential to optimize outcomes and minimize risks. This study aimed to characterize laboratory and clinical parameter changes following NexoBrid application in patients with small burn injuries (≤10% TBSA).
View Article and Find Full Text PDFNormothermic Machine Perfusion and Inflammatory Mediators Adsorption: First Kidney Transplant Experience.
ASAIO J
July 2025
From the Department of Abdominal Center, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione) Palermo, Italy.
Kidney transplantation faces challenges due to the shortage of donor organs, leading to the increased use of extended criteria donor (ECD) organs. Recent advancements in ex-situ organ perfusion technologies have facilitated the use of ECD kidneys by preserving organs in near-physiological conditions to tackle ischemia-reperfusion injury (IRI), a process that leads to long-term graft injury. This study focuses on the application of an inflammatory mediators' removal (IMR) integrated in a normothermic machine perfusion (NMP) for the recovery of an ECD kidney before transplantation.
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