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We report the case of a 38-year-old female presenting with posterior reversible encephalopathy syndrome (PRES) overlapping with reversible cerebral vasoconstriction syndrome (RCVS), diagnosed based on clinical and imaging criteria. The patient exhibited progressive neurological symptoms, including headache, visual disturbances, and motor deficits. Brain magnetic resonance angiography revealed vasogenic edema and vascular stenoses. The complications included severe agitation, sympathetic hyperreactivity, and features suggestive of serotonin syndrome. The management focused on blood pressure control, symptom management, and medication adjustment. Despite significant improvement during hospitalization and rehabilitation, residual deficits persisted. This report highlights the complex interplay between PRES and RCVS, emphasizing the importance of serial neuroimaging, systematic medication reviews, and a multidisciplinary approach in managing such overlapping conditions.
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http://dx.doi.org/10.7759/cureus.88916 | DOI Listing |
Commun Biol
September 2025
Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK.
Primate lateral intraparietal area (LIP) has been directly linked to perceptual categorization and decision-making. However, the intrinsic LIP circuitry that gives rise to the flexible generation of motor responses to sensory instruction remains unclear. Using retrograde tracers, we delineate two distinct operational compartments based on different intrinsic connectivity patterns of dorsal and ventral LIP.
View Article and Find Full Text PDFPsychoradiology
August 2025
Department of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Background: Despite advances in understanding the effective connectivity (EC) of brain networks in leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis, the specific cause and underlying mechanisms of LGI1 encephalitis remain unclear.
Materials And Methods: The study included 27 patients with anti-LGI1 encephalitis and 28 age- and sex-matched normal controls. Amplitude of low-frequency fluctuation (ALFF) analysis identified altered brain regions.
JOR Spine
September 2025
Spine Center, Department of Orthopaedics Changzheng Hospital, Naval Medical University (Second Military Medical University) Shanghai People's Republic of China.
Background: Ossification of the posterior longitudinal ligament (OPLL) is a pathological condition characterized by ectopic ossification of spinal ligaments, primarily driven by abnormal osteogenic differentiation of ligament fibroblasts with stem cell-like properties. The SOX transcription factor family is crucial in regulating cell stemness and differentiation. Among them, SOX8 is known to influence osteoblast differentiation, but its role in OPLL remains unclear.
View Article and Find Full Text PDFJ Shoulder Elbow Surg
September 2025
ARTORG Center for Biomedical Engineering, University of Bern, Bern, Switzerland.
Introduction: Rotator cuff muscle pathology affects outcomes following total shoulder arthroplasty, yet current assessment methods lack reliability in quantifying muscle atrophy and fat infiltration. We developed a deep learning-based model for automated segmentation of rotator cuff muscles on computed tomography (CT) and propose a T-score classification of volumetric muscle atrophy. We further characterized distinct atrophy phenotypes, 3D fat infiltration percentage (3DFI%), and anterior-posterior (AP) balance, which were compared between healthy controls, anatomic total shoulder arthroplasty (aTSA), and reverse total shoulder arthroplasty (rTSA) patients.
View Article and Find Full Text PDFJ Shoulder Elbow Surg
September 2025
Institute for Orthopaedic Research and Training (IORT), Department of Development and Regeneration, Faculty of Medicine, KU Leuven, Leuven, Belgium; Division of Orthopaedics, University Hospitals Leuven, Leuven, Belgium.
Background: The use of reverse total shoulder arthroplasty (rTSA) has increased in recent years, thanks to its application versatility. Despite this increase, there exists a significant variability in postoperative functional internal rotation (fIR), affecting patients' daily life independence. Previous literature investigated patient-related, kinematical, and surgical parameters to understand the variability in fIR outcome.
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