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Article Abstract
RDE-3 adds poly UG tails to mRNAs targeted for silencing by the dsRNA-initiated RNA interference (RNAi) pathway. RDE-3 can also add p(UG) tails to some endogenous cellular mRNAs. Mechanisms directing RDE-3 to pUGylate specific mRNAs are not understood. Here we show that the miRNA directs pUGylation of an intestine-specific mRNA , which leads to silencing of the mRNA. The data show that genome-encoded small regulatory RNAs are one mechanism by which RDE-3 can be directed to pUGylate specific mRNAs for gene regulation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381656 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.001754 | DOI Listing |
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