Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1002/ejhf.3787DOI Listing

Publication Analysis

Top Keywords

sodium zirconium
4
zirconium cyclosilicate
4
cyclosilicate hyperkalaemia
4
hyperkalaemia spironolactone
4
spironolactone optimization
4
optimization heart
4
heart failure
4
failure reduced
4
reduced ejection
4
ejection fraction
4

Similar Publications

Hyperkalemia is a common and serious complication in dialysis patients, with increased incidence and severity over time. Newer potassium binders, patiromer and sodium zirconium cyclosilicate (SZC), offer improved tolerability compared to older agents. This meta-analysis aims to evaluate the efficacy and safety of these newer binders in dialysis patients.

View Article and Find Full Text PDF

Recent advancements in drug delivery systems have transformed drug administration methods to ensure precise, targeted delivery with minimal side effects. Innovations involving polymer-metal organic frameworks can significantly improve drug stability and controlled release properties. In this study, a drug delivery system based on a zirconium metal organic framework (Zr-MOF), sodium alginate (SA), and polyvinylpyrrolidone (PVP) was developed.

View Article and Find Full Text PDF

Background: Sodium zirconium cyclosilicate (SZC, Lokelma) is a novel hyperkalemia therapy, but comprehensive real-world safety data are lacking. This study aimed to characterize SZC-associated adverse events (AEs) using post-marketing surveillance.

Research Design And Methods: AE reports for SZC/Lokelma were extracted from the FDA Adverse Event Reporting System (FAERS) (2004-2023).

View Article and Find Full Text PDF

A Safe MRI- and PET-guided Method for Increasing Osmotic Blood-Brain Barrier Permeability.

Radiology

September 2025

Department of Diagnostic Radiology and Nuclear Medicine, School of Medicine, University of Maryland, 670 W Baltimore St, Baltimore, MD 21201.

Background Given the current lack of widely adopted strategies for facilitating drug penetration into the brain, developing new techniques to increase blood-brain barrier (BBB) permeability is essential to address the increasing burden of central nervous system disorders. Osmotic blood-brain barrier opening (OBBBO), achieved through intra-arterial delivery of 25% mannitol to the cerebral vasculature, is a pioneering strategy demonstrating both safety and partial efficacy. Purpose To investigate the potential of 25% mannitol with 4% NaCl, a combination that doubles the osmotic power, to safely increase OBBBO efficacy.

View Article and Find Full Text PDF