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Article Abstract
Secreted Frizzled-related proteins (SFRPs) are a small, ancient family of extracellular signaling pathway agonists and antagonists. In this study, we examined their expression patterns during regeneration in the holothurian Eupentacta fraudatrix using whole-mount in situ hybridization. Our results suggest that both genes are involved in proper water-vascular system formation and coelomic epithelium homeostasis in holothurians.
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