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DNA nanotechnology enables the precise construction of intricate nanoscale structures. Over the past two decades, significant progress has been made in incorporating dynamic functionalities into these nanostructures. Concurrently, innovative strategies have emerged for their self-assembly and surface patterning into larger, more complex architectures. This review explores the convergence of these two key capabilities-reconfigurability and hierarchical assembly-to engineer DNA origami superstructures with intrinsic dynamic behavior. We begin by outlining foundational strategies in dynamic design, hierarchical assembly, and surface placement, then review recent progress in leveraging these strategies to construct dynamic superstructures with emergent behaviors. The article concludes with a roadmap of major challenges and opportunities shaping the future of this rapidly evolving field.
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http://dx.doi.org/10.1039/d5nh00436e | DOI Listing |
J Am Chem Soc
September 2025
State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
The discovery of new weak supramolecular interactions and supramolecular synthons is essential for directing self-assembly processes with enhanced precision, diversity, and functionality in complex molecular architectures. Here, we report the controlled self-assembly of diverse supramolecular architectures by a new directional bonding approach through the integration of radical-based dynamic covalent chemistry and supramolecular synthons. A novel macrocyclic synthon, , with a linear direction is constructed via radical-based dynamic covalent bonds from the phenothiazine building block substituted with two dicyanomethyl radicals.
View Article and Find Full Text PDFNano Lett
September 2025
School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China.
Multijunction photoelectrodes, which generate active photocarriers with sufficient energy to drive unassisted solar-fuel conversion, represent a promising avenue for sustainable energy applications. However, achieving controllable p/n-type doping and high-quality growth remains a challenge for most emerging metal oxide semiconductors. In this study, we demonstrate the creation of in-plane ferroelectric p/n homojunction superstructures in BiFeO (BFO) films, enabling bias-free photoelectrochemical (PEC) reactions.
View Article and Find Full Text PDFNanoscale Horiz
August 2025
Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
DNA nanotechnology enables the precise construction of intricate nanoscale structures. Over the past two decades, significant progress has been made in incorporating dynamic functionalities into these nanostructures. Concurrently, innovative strategies have emerged for their self-assembly and surface patterning into larger, more complex architectures.
View Article and Find Full Text PDFChem Commun (Camb)
August 2025
School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, China.
We report on the dynamic self-assembly of TiO-Fe photocatalytic colloidal motors into reconfigurable superstructures when subjected to UV illumination, magnetic fields, and acoustic confinement. Tuning the light intensity and magnetic field strength enables control over cluster size, rotation speed, and structural compactness. Four distinct phases emerge from the interplay of dipolar repulsion, self-propulsion, and phoretic attraction.
View Article and Find Full Text PDFACS Nano
September 2025
College of Chemistry and Chemical Engineering, Key Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province, Qufu Normal University, Qufu, Shandong 273165, China.
The transformation of metal nanocluster (MNC)-based heterochiral assemblies into their homochiral analogues is a compelling goal inspired by the ubiquitous homochirality observed in living systems. Owing to the intricate factors governing nanomaterial chirality, the precise control of supramolecular chirality in MNCs remains rarely demonstrated. Herein, we demonstrated the coassembly behavior of AuNCs protected by 6-propyl-2-thiouracil (AuPRT) with chiral mandelic acid (MA), which revealed the formation of hybrid chiral superstructures of - and -helices in a single system.
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