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Purpose: To provide references for the selection of restoration types and materials for the first premolar with large defect in clinical practice.
Methods: A large area defect model of the maxillary first premolar was established and repaired with different types and materials, including group A (inlay group), group B (endocrown group), group C (fiber post core crown group), and group D (pure titanium post core crown group). And then, according to different repair materials, it was divided into 3 subgroups, namely group 1 (zirconia), group 2 (glass ceramic), and group 3 (resin based ceramic), totaling 12 groups. The stress distribution and magnitude were investigated using finite element analysis software.
Results: In the inlay group, the stress concentration area was large and tended to spread along the neck of tooth; in the post core crown group and endocrown group, the stress distribution was more uniform. In terms of restorative materials for endocrown, resin based ceramic materials had the lowest stress, followed by glass ceramic materials, and zirconia materials had the highest stress.
Conclusions: Large defects of the first premolar can be repaired with endocrowns and post core crowns, and endocrowns have good applicability and advantages. Resin based ceramic materials are recommended for the selection of the endocrown materials for the least stress of the remaining tooth.
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Orthop Rev (Pavia)
September 2025
Introduction/background: Complex articular fractures around the knee in the elderly patient present an ongoing challenge regarding optimal treatment. While extensive research has evaluated immediate arthroplasty following fracture of the proximal femur, distal femur, proximal humerus, and elbow, relatively little focus has been given to immediate arthroplasty following complex tibia plateau fractures.
Methods: As seen with many other fractures, arthroplasty can shorten recovery and hospital stay and allow early weight-bearing with improved mobility while minimizing complications and possible future conversion arthroplasty cost.
Palliat Med Rep
May 2025
Family Medicine, Hamilton Health Sciences, Grimsby, Canada.
Background: In Canada, access to palliative care varies across jurisdictions. Many health care professionals lack core palliative care competencies. To help build capacities, a pilot education program was conducted at a community hospital in Southwestern Ontario (Canada).
View Article and Find Full Text PDFJ Neurochem
September 2025
Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, USA.
The two most prominent post-translational modifications of pathologic tau are Ser/Thr/Tyr phosphorylation and Lys acetylation. Whether acetylation impacts the susceptibility of tau to templated seeding in diseases like Alzheimer's disease (AD) and Progressive Supranuclear Palsy (PSP) is largely uncharacterized. Towards this, we examined how acetylation mimicking or nullifying mutations on five sites of tau (K311, K353, K369, K370, K375), located within the tau filament core, influenced the susceptibility of P301L (PL) tau to seeds from AD (AD-tau) or PSP (PSP-tau) brain donors in HEK293T cells.
View Article and Find Full Text PDFAust N Z J Psychiatry
September 2025
Department of Psychological Medicine, Sydney Children's Hospitals Network, Sydney, NSW, Australia.
Objective: Art therapy offers a predominantly non-verbal form of creative self-expression for people experiencing mental health issues. This systematic review aims to investigate the effectiveness and acceptability of art therapy for children and adolescents experiencing acute or severe mental health conditions.
Methods: Following PRISMA guidelines, five electronic databases were searched (Embase, MEDLINE, Web of Science Core Collection, PsychINFO, CINAHL) using the search terms ('art therap*' OR 'art psychotherap*') AND ('child*' OR 'adolescen*' OR 'youth' OR 'young' OR 'teen*').
Diabetes Obes Metab
September 2025
Eli Lilly and Company, Indianapolis, Indiana, USA.
Aims: To determine whether adults with type 2 diabetes (T2D) treated with retatrutide report greater changes in self-reported appetite, dietary restraint, and disinhibition compared to placebo or dulaglutide and to examine associations with weight change.
Materials And Methods: These pre-specified exploratory analyses examined changes from baseline in Appetite Visual Analogue Scale (VAS) and Eating Inventory (EI) scores after 24 and 36 weeks of once-weekly treatment with placebo, dulaglutide 1.5 mg, or retatrutide 0.