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Bowel sonography comprises the study of inflammatory bowel disease (IBD) and other inflammatory and neoplastic bowel conditions associated with gross morphologic change. For the most common application, IBD, it is well established that gray-scale US and color Doppler US imaging (CDI) allow excellent assessment of the status of the bowel wall, blood flow to the bowel and mesentery, and the presence or absence of perienteric inflammatory fat. Although these techniques provide effective and accurate methods to assess the bowel, they are not always comprehensive. Bowel loops residing in the true pelvis may not be accessible from a transabdominal approach, and CDI is not sensitive at increased depths and in patients with obesity. Most important, CDI only shows fast-moving flow in large blood vessels, with a limited ability to show blood flow at the microvascular level. Bowel stiffness is also not included in a standard gray-scale assessment. Three readily available ancillary US techniques can be used to overcome these imaging challenges and to greatly improve detection of pathologic conditions and patient outcomes. These techniques are endovaginal US to visualize pathologic conditions in the deep pelvis, contrast-enhanced US to subjectively and objectively assess blood flow to the capillary level, and two-dimensional shear-wave elastography to determine bowel stiffness as a measure of disease chronicity. The authors provide a detailed description of the application of these techniques with case examples demonstrating the added benefit. RSNA, 2025 Supplemental material is available for this article. See the invited commentary by Barr in this issue.
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http://dx.doi.org/10.1148/rg.240149 | DOI Listing |
Biomater Sci
September 2025
School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia.
The increasing use of blood-contacting medical devices has brought about significant advancements in patient care, yet it also presents challenges such as thrombus formation and infection risks. Surface coatings play a vital role in mitigating these side effects, enhancing the safety and effectiveness of such devices. In this study, we introduced a novel coating employing poly(aspartic acid) (PASP), which can be easily applied through various modification pathways.
View Article and Find Full Text PDFInflamm Res
September 2025
Department of General Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Chaoyang District, Beijing, 100029, China.
Background: The roles of long non-coding RNAs (lncRNAs) in the progression of various human tumors have been extensively studied. However, their specific mechanisms and therapeutic potential in Triple-Negative Breast Cancer (TNBC) remain to be fully elucidated.
Materials And Methods: The qRT-PCR assay was utilized to assess the relative mRNA levels of TFAP2A-AS1, PHGDH, and miR-6892.
Minerva Anestesiol
September 2025
Department of Cardiac, Thoracic and Vascular Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Background: Postoperative cognitive dysfunction (POCD) occurs in 20% to 80% of patients following cardiac surgical interventions. The incidence of delirium is from 20% to 50%. Impaired cerebral autoregulation (CA) during cardiopulmonary bypass (CPB) contributes to these issues.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
September 2025
Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, United States.
Purpose: To assess macular choriocapillaris (CC) metrics in healthy volunteers (HVs) without ocular disease and demonstrate CC variations in patients with inherited retinal dystrophies (IRDs) using adaptive optics optical coherence tomography angiography (AO-OCTA).
Methods: Twenty-one HVs and three IRD patients were imaged. Macular variation in 20 HVs in CC metrics (CC density, CC diameter, CC tortuosity, void diameter, void area, lobule count, lobule area, and RPE-CC distance) were assessed by imaging a 28° strip of overlapping AO-OCTA volumes (3° × 3°) from the optic nerve head to the temporal macula.
J Pediatr Hematol Oncol
September 2025
Children's Hospital of Michigan, Division of Hematology/Oncology.
Glanzmann thrombasthenia (GT) is a rare autosomal recessive platelet disorder characterized by abnormalities in platelet aggregation, resulting from quantitative or qualitative defects in integrins αIIb and β3. Currently, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only potentially curative therapeutic approach for severe GT. In this report, we present 2 children with GT that underwent successful allo-HSCT, along with 2008 to 2022 data from the Center for International Blood and Marrow Transplant Research and a summary of the existing literature providing further evidence that allo-HSCT can be a curative approach that prevents severe and life-threatening bleeding in GT.
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