Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The antioxidant α1-microglobulin (A1M) has been suggested as kidney protector during 177Lu-octreotate treatment. The aim of this work was to evaluate apoptotic-related transcript expression in kidney cortex and medulla following injection of 177Lu-octreotate and/or A1M. Mice were injected with 177Lu-octreotate, A1M, or 177Lu-octreotate + A1M. Control groups received PBS or vehicle solution. Animals were killed after 24 hours or 7 d. mRNA was isolated from kidney medulla and cortex. Expression of 84 apoptosis-related genes was assessed by q-PCR. Gene expression profiles in kidney cortex were generally similar in the 177Lu-octreotate and 177Lu-octreotate + A1M groups. This was also seen in kidney medulla at 24 hours, but at 7 d anti-apoptotic response of A1M was observed. Altogether, 177Lu-octreotate exposure induced pro-apoptotic response (e.g. Apaf1, Bax, and Tnfrsf10b genes) in kidney medulla and cortex. A1M co-administration did not inhibit pro-apoptotic response in kidney cortex, while A1M initiated pro-survival mechanisms in kidney medulla.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392902 | PMC |
| http://dx.doi.org/10.1093/rpd/ncaf055 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Shiga Toxin Type 2 Aggravates G1/S Phase Cell Cycle Arrest, Mediating Caspase-Independent Cell Death under Hyperosmotic Conditions in the Kidney.
J Microbiol Biotechnol
September 2025
Environmental Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Shiga toxin (Stx) is a virulence factor produced by serotype 1 and Stx-producing (STEC). It causes severe renal damage, leading to hemolytic uremic syndrome (HUS). The main target organ of Stx, the kidney, plays a role in maintaining water homeostasis in the body by increasing an osmotic gradient from the cortex to the medulla.
View Article and Find Full Text PDFUltrasound elastographic evaluation of renal parenchyma in pediatric patients with vesicoureteral reflux.
J Pediatr Urol
August 2025
Gaziantep University Medical Faculty, Department of Urology, Gaziantep, Turkey. Electronic address:
Objective: The most common chronic complication of vesicoureteral reflux (VUR) is the presence of renal scarring and dimercapto succinic acid (DMSA) renal scan is utilized for its detection. In this study, we have aimed to assess whether shear wave speed (SWS) differs between normal and refluxing kidneys.
Materials And Method: Fifty pediatric VUR patients and 21 healthy children with available DMSA obtained within the previous year were included in the study.
Influence of perinatal exposure to an endocrine disruptor mixture on the renal microenvironment of aged male rat offspring: histopathological aspects.
J Dev Orig Health Dis
September 2025
Graduate Program in Health Science, Western São Paulo University (UNOESTE), Presidente Prudente, SP, Brazil.
The developmental origins of health and disease hypothesis suggests that environmental exposures during critical developmental windows increase the risk of disease later in life. Among these, endocrine disruptors (EDs) are particularly concerning due to their ubiquitous presence. The kidneys are highly susceptible to EDs toxicity during the perinatal period; however, long-term effects of ED mixtures on renal structure in aging remain unclear.
View Article and Find Full Text PDFEarly apoptotic response in kidney after 177Lu-octreotate administration with or without potential radioprotector α1-microglobulin.
Radiat Prot Dosimetry
August 2025
Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
The antioxidant α1-microglobulin (A1M) has been suggested as kidney protector during 177Lu-octreotate treatment. The aim of this work was to evaluate apoptotic-related transcript expression in kidney cortex and medulla following injection of 177Lu-octreotate and/or A1M. Mice were injected with 177Lu-octreotate, A1M, or 177Lu-octreotate + A1M.
View Article and Find Full Text PDFDiffusion kurtosis imaging and arterial spin labeling MRI for assessment of post-contrast acute kidney injury risk in rats with subclinical kidney injury.
BMC Nephrol
August 2025
Department of Radiology, Tianjin First Central Hospital, Tianjin Institute of Imaging Medicine, 24 Fukang Road, Nankai District, Tianjin, China.
Background: The risk of post-contrast acute kidney injury (PC-AKI) following subclinical acute kidney injury (sAKI) remains unclear. This study was performed to determine whether sAKI increases the risk of PC-AKI and to assess the utility of multiparametric MRI, including diffusion kurtosis imaging (DKI) and arterial spin labeling (ASL), for detecting pathological changes with high sensitivity.
Methods: A rat model of subclinical kidney injury was established through subcutaneous injection of carbon tetrachloride for 6 weeks.