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Self-expanding metallic stents (SEMSs) are an established palliative option for malignant colonic obstruction, including in cases with proximal lesions. However, SEMS placement across the ileocecal valve (ICV) can be technically challenging because of the anatomical curvature and luminal stenosis. Herein, we report a successful case of colonic stenting for a malignant ileocecal obstruction using an ultra-thin scope and a single-balloon overtube. A 72-year-old man with alcoholic cirrhosis and multiple liver metastases presented with malignant ileocecal obstruction. Given his inoperability, palliative SEMS placement was attempted. Colonoscopy showed a circumferential tumor in the ileocecum, with no passage of contrast medium into the ileum. Guidewire insertion across the ICV failed because of the inability to visualize the direction of the ileal lumen. To overcome this, we used a rescue technique with an ultra-thin scope and a single-balloon overtube. After placing the overtube in the ascending colon, the ultra-thin scope was advanced through it to explore the stenotic lumen directly. This allowed safe insertion of the guidewire into the proximal lumen of the stenosis. The ultra-thin scope was withdrawn, and a standard scope was inserted over the guidewire. Finally, a SEMS was deployed across the ICV through the scope. The patient's obstructive symptoms were resolved without complications, and he was discharged 7 days later. This case demonstrates that in cases of malignant ileocecal obstruction where SEMS placement using conventional methods is difficult, a rescue technique using an ultra-thin scope with a single-balloon overtube may be a viable alternative.
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http://dx.doi.org/10.1002/deo2.70190 | DOI Listing |
Self-expanding metallic stents (SEMSs) are an established palliative option for malignant colonic obstruction, including in cases with proximal lesions. However, SEMS placement across the ileocecal valve (ICV) can be technically challenging because of the anatomical curvature and luminal stenosis. Herein, we report a successful case of colonic stenting for a malignant ileocecal obstruction using an ultra-thin scope and a single-balloon overtube.
View Article and Find Full Text PDFArch Ital Urol Androl
June 2025
CDC Ambrosiana, Cesano Boscone (MI).
The formation of kidney stones is a complex biologic process involving interactions among genetic, anatomic, dietary, and environmental factors. Traditional lithogenic models were based on urine supersaturation in relation to the activity of crystallization promoters and inhibitors. However, modern research has added new principles such as the "renal epithelial cell response" and the role of inflammation and oxidative stress leading to the development of a "multi-hit hypothesis".
View Article and Find Full Text PDFSoft Matter
April 2025
Laboratory of Physical Chemistry and Soft Matter, Wageningen University & Research, Wageningen, The Netherlands.
Lipid-based vesicles are widely used, minimalistic model containers for reconstitution of biological systems and engineering synthetic cells. These containers provide a micro-chassis to encapsulate biomolecules and study biochemical interactions. Liposomes are often the most sought-after vesicles owing to their cell-mimicking nature, and numerous bulk and on-chip methods exist for their production.
View Article and Find Full Text PDFJ Esthet Restor Dent
July 2025
Clinical and Scientific Director, Fahl Center, Curitiba, Brazil.
Objective: This clinical report seeks to elucidate the versatility and mid-term outcomes of the direct-indirect technique. It presents a comprehensive step-by-step protocol for restoring anterior dentition across various clinical scenarios in accordance with the principles of the polychromatic layering technique.
Clinical Considerations: This clinical report was divided into two phases.
Rev Sci Instrum
December 2024
Tata Institute of Fundamental Research Hyderabad, Sy No 36/P, Serilingampally Mandal, Hyderabad 500046, India.
Ultra-low magnetic field sensing is emerging as a tool for materials' diagnostics, particularly for the operando studies of electrochemical systems. A magnetic metrology system having the capability of sensing fields as low as ∼1.88 pT has been setup for such studies using a commercial atomic magnetometer.
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