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The Canadian Association for the Study of the Liver and Association of Medical Microbiology and Infectious Disease Canada developed jointly the 2025 guidelines for the management of chronic hepatitis B in May 2025. The guidelines updated recommendations for universal adult HBV screening, vaccination, laboratory assessment, treatment, patient-centered care, early diagnosis, expanding antiviral treatment. Notably, the guidelines recommend reflex HDV testing and routine use of quantitative HBsAg for the decision of HBV management.
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http://dx.doi.org/10.3760/cma.j.cn501113-20250630-00257 | DOI Listing |
Diabetologia
September 2025
Department of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
This review article, developed by the EASD Global Council, addresses the growing global challenges in diabetes research and care, highlighting the rising prevalence of diabetes, the increasing complexity of its management and the need for a coordinated international response. With regard to research, disparities in funding and infrastructure between high-income countries and low- and middle-income countries (LMICs) are discussed. The under-representation of LMIC populations in clinical trials, challenges in conducting large-scale research projects, and the ethical and legal complexities of artificial intelligence integration are also considered as specific issues.
View Article and Find Full Text PDFEur Geriatr Med
September 2025
School of Public Health Sciences, University of Waterloo, Waterloo, Canada.
Purpose: Sleep disturbance is prevalent in long-term care facilities (LTCFs), yet there is limited understanding of individual factors predicting changes in sleep within these populations. Our objective was to determine predictors of sleep disturbance in LTCFs and investigate variation in prevalence across facilities in two Canadian provinces-New Brunswick and Saskatchewan.
Method: This retrospective longitudinal cohort study used interRAI comprehensive health assessment data from 2016 to 2021, encompassing 21,394 older adults aged ≥ 65 years across 228 LTCFs.
Drugs Aging
September 2025
Dalla Lana School of Public Health, University of Toronto, V1 06, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Background And Objectives: Older adults living with dementia are a heterogeneous group, which can make studying optimal medication management challenging. Unsupervised machine learning is a group of computing methods that rely on unlabeled data-that is, where the algorithm itself is discovering patterns without the need for researchers to label the data with a known outcome. These methods may help us to better understand complex prescribing patterns in this population.
View Article and Find Full Text PDFMicrobiol Resour Announc
September 2025
Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
We report the genome sequences of two -infecting siphophages, B1VFA and V1VFA-S, isolated from Canadian agricultural soils. Both encode genes associated with plasmid maintenance, including , , and , and share similar genome architecture. These phages expand the diversity of rhizobiophages and may represent a distinct siphophage lineage.
View Article and Find Full Text PDFInfect Control Hosp Epidemiol
September 2025
Children's Hospital of Eastern Ontario, Ottawa, Canada.