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Ultrasound imaging is widely used in early pregnancy to screen for fetal brain anomalies. However, the accuracy of diagnosis can be influenced by various factors, including the sonographer's experience and environmental conditions. To address these limitations, advanced methods are needed to enhance the efficiency and reliability of fetal anomaly screening. In this study, we propose a novel approach based on a Fetal Brain Structures Detection Network (FBStrNet) for identifying key anatomical structures in fetal brain ultrasound images. Specifically, FBStrNet builds on the YOLOv5 baseline model, incorporating a lightweight backbone to reduce model parameters, replacing the loss function, and utilizing a decoupled detection header to improve accuracy. Additionally, our method integrates prior clinical knowledge to minimize false detection rates. Experimental results demonstrate that FBStrNet outperforms state-of-the-art methods, achieving real-time detection of fetal brain anatomical structures with an inference time of just 11.5 ms. This capability enables sonographers to efficiently visualize critical anatomical features, thereby improving diagnostic precision and streamlining clinical workflows.
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http://dx.doi.org/10.3390/s25165034 | DOI Listing |
Nat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
View Article and Find Full Text PDFPediatr Res
September 2025
Laboratory of Fetal Neuroprogramming, Institute of Health Sciences, University of O'Higgins, Rancagua, Chile.
Background: Fetal growth restriction (FGR) causes an adaptive redistribution of the cardiac output towards sustained cerebral vasodilation. However, the consequences of FGR and cerebral vasodilatation due to fetal hypoxia on the blood-brain barrier (BBB) are still poorly studied. This study assesses BBB permeability in the neonatal cortex of pups gestated under intrauterine hypobaric hypoxia.
View Article and Find Full Text PDFAm J Hum Genet
September 2025
Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, Rotterdam 3000 CA, the Netherlands.
Microtubule-actin cross-linking factor 1 (MACF1) is a large protein of the spectraplakin family, which is essential for brain development. MACF1 interacts with microtubules through the growth arrest-specific 2 (Gas2)-related (GAR) domain. Heterozygous MACF1 missense variants affecting the zinc-binding residues in this domain result in a distinctive cortical and brain stem malformation.
View Article and Find Full Text PDFReprod Biomed Online
May 2025
Department of Obstetrics and Gynaecology, and Neonatology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynaecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Med
Research Question: What is the global, regional and national burden of polycystic ovary syndrome (PCOS), particularly in adolescents, based on data from the Global Burden of Disease (GBD) 2021 study?
Design: Prevalence, incidence and years lived with disability (YLD) for PCOS were extracted from the GBD 2021 database, standardized via Bayesian meta-regression, and stratified by age, region and Socio-Demographic Index (SDI). Temporal trends (1990-2021) were presented, and future projections (to 2045) were modelled using autoregressive integrated moving average models.
Results: Between 1990 and 2021, the global prevalence of PCOS increased from 36.
JAACAP Open
September 2025
University of Calgary, Calgary, Alberta, Canada.
Objective: Psychological distress (eg, anxiety and depression) during pregnancy can disrupt fetal brain development and negatively affect infant behavior. Prenatal distress rose substantially during the COVID-19 pandemic according to most, but not all, studies, raising concerns about its potential effects on brain connectivity and behavior in infants.
Method: We investigated 63 mother-infant pairs as part of the Pregnancy during the COVID-19 Pandemic study.